Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3829059..3829857 Replicon chromosome
Accession NZ_CP024138
Organism Escherichia coli strain 14EC020

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag CR537_RS19905 Protein ID WP_000854730.1
Coordinates 3829480..3829857 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag CR537_RS19900 Protein ID WP_001285481.1
Coordinates 3829059..3829433 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR537_RS19860 3825034..3825486 + 453 WP_000682723.1 hypothetical protein -
CR537_RS19865 3825604..3825837 + 234 WP_001213776.1 DUF905 family protein -
CR537_RS19870 3825937..3826758 + 822 WP_001234359.1 DUF945 domain-containing protein -
CR537_RS19875 3826758..3827003 + 246 WP_001164966.1 hypothetical protein -
CR537_RS19880 3827097..3827570 + 474 WP_001313575.1 antirestriction protein -
CR537_RS19885 3827586..3828062 + 477 WP_001313574.1 RadC family protein -
CR537_RS19890 3828125..3828346 + 222 WP_000692315.1 DUF987 domain-containing protein -
CR537_RS19895 3828365..3829009 + 645 WP_000086759.1 hypothetical protein -
CR537_RS19900 3829059..3829433 + 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CR537_RS19905 3829480..3829857 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
CR537_RS19910 3829854..3830346 + 493 Protein_3652 hypothetical protein -
CR537_RS19915 3830425..3831413 - 989 Protein_3653 IS630 family transposase -
CR537_RS19920 3831561..3833154 - 1594 Protein_3654 IS66 family transposase -
CR537_RS19925 3833185..3833535 - 351 WP_000624707.1 IS66 family insertion sequence element accessory protein TnpB -
CR537_RS19930 3833532..3833823 - 292 Protein_3656 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T86893 WP_000854730.1 NZ_CP024138:3829480-3829857 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T86893 NZ_CP024138:3829480-3829857 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT86893 WP_001285481.1 NZ_CP024138:3829059-3829433 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT86893 NZ_CP024138:3829059-3829433 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References