Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4672089..4672887 Replicon chromosome
Accession NZ_CP024134
Organism Escherichia coli strain 14EC017

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag CR536_RS25100 Protein ID WP_000854735.1
Coordinates 4672510..4672887 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag CR536_RS25095 Protein ID WP_032153712.1
Coordinates 4672089..4672463 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR536_RS25055 4667822..4668706 + 885 WP_024166630.1 50S ribosome-binding GTPase -
CR536_RS25060 4668825..4669502 + 678 WP_023155728.1 hypothetical protein -
CR536_RS25065 4669532..4669741 + 210 WP_023155727.1 DUF905 family protein -
CR536_RS25070 4669832..4670650 + 819 WP_001234693.1 DUF945 domain-containing protein -
CR536_RS25075 4670742..4671227 + 486 WP_032153711.1 antirestriction protein -
CR536_RS25085 4671243..4671719 + 477 WP_001186715.1 RadC family protein -
CR536_RS25090 4671788..4672009 + 222 WP_000692345.1 DUF987 domain-containing protein -
CR536_RS25095 4672089..4672463 + 375 WP_032153712.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
CR536_RS25100 4672510..4672887 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
CR536_RS25105 4672884..4673375 + 492 WP_023155722.1 hypothetical protein -
CR536_RS25110 4673387..4673584 + 198 WP_000839265.1 DUF957 domain-containing protein -
CR536_RS25115 4673669..4674535 + 867 WP_032153714.1 DUF4942 domain-containing protein -
CR536_RS25120 4674607..4674870 + 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
CR536_RS25125 4674867..4675193 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 papB / papI / espK / espK / espF / escG / escF / cesD2 / espB / espD / espA / sepL / escD / eae / cesT / tir / map / cesF / espH / sepQ/escQ / escO / escN / escV / cesL / sepZ/espZ / escI / escJ / sepD / escC / cesD / etgA / escU / escT / escS / escR / escL / escK / cesAB / escE / espG 4607713..4716399 108686


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T86856 WP_000854735.1 NZ_CP024134:4672510-4672887 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T86856 NZ_CP024134:4672510-4672887 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT86856 WP_032153712.1 NZ_CP024134:4672089-4672463 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT86856 NZ_CP024134:4672089-4672463 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References