Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4418674..4419488 Replicon chromosome
Accession NZ_CP024127
Organism Escherichia coli strain 14EC001

Toxin (Protein)


Gene name yjhX Uniprot ID A0A6C9SL90
Locus tag CR534_RS23810 Protein ID WP_001054375.1
Coordinates 4418674..4418931 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag CR534_RS23815 Protein ID WP_001309181.1
Coordinates 4418943..4419488 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR534_RS23780 4413962..4415068 + 1107 WP_001299704.1 N-acetylneuraminate epimerase -
CR534_RS23785 4415133..4416113 + 981 WP_000991455.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
CR534_RS23790 4416696..4417936 - 1241 Protein_4322 helicase YjhR -
CR534_RS23800 4418052..4418297 + 246 Protein_4323 GNAT family N-acetyltransferase -
CR534_RS23810 4418674..4418931 + 258 WP_001054375.1 hypothetical protein Toxin
CR534_RS23815 4418943..4419488 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
CR534_RS23820 4419544..4420290 + 747 WP_000354252.1 class I SAM-dependent methyltransferase -
CR534_RS23825 4420459..4420677 + 219 Protein_4327 hypothetical protein -
CR534_RS29365 4420715..4420831 + 117 Protein_4328 VOC family protein -
CR534_RS23830 4421076..4422197 + 1122 WP_000010831.1 M42 family metallopeptidase -
CR534_RS23835 4422194..4422472 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
CR534_RS23840 4422484..4423797 + 1314 WP_021558205.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9768.31 Da        Isoelectric Point: 11.0090

>T86801 WP_001054375.1 NZ_CP024127:4418674-4418931 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QFDNR

Download         Length: 258 bp

>T86801 NZ_CP024127:4418674-4418931 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGTTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19938.86 Da        Isoelectric Point: 6.3277

>AT86801 WP_001309181.1 NZ_CP024127:4418943-4419488 [Escherichia coli]
ITVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT86801 NZ_CP024127:4418943-4419488 [Escherichia coli]
ATAACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACTGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C9SL90

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References