Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 79628..80463 | Replicon | chromosome |
| Accession | NZ_CP024127 | ||
| Organism | Escherichia coli strain 14EC001 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A7W4PV54 |
| Locus tag | CR534_RS00465 | Protein ID | WP_000854821.1 |
| Coordinates | 79628..80005 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | CR534_RS00470 | Protein ID | WP_101981452.1 |
| Coordinates | 80095..80463 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CR534_RS00420 | 75441..75848 | + | 408 | WP_000228584.1 | LcrR family type III secretion system chaperone CesD2 | - |
| CR534_RS00425 | 75882..76103 | + | 222 | WP_001053840.1 | type III secretion system LEE needle filament protein EscF | - |
| CR534_RS00430 | 76109..76387 | + | 279 | WP_000245815.1 | type III secretion system LEE needle protein cochaperone EscG | - |
| CR534_RS00435 | 76472..77224 | + | 753 | WP_101981451.1 | type III secretion system LEE effector EspF | - |
| CR534_RS00440 | 77507..77814 | - | 308 | Protein_85 | IS3 family transposase | - |
| CR534_RS00450 | 78282..79124 | - | 843 | WP_001696593.1 | DUF4942 domain-containing protein | - |
| CR534_RS00455 | 79209..79406 | - | 198 | WP_086795284.1 | DUF957 domain-containing protein | - |
| CR534_RS00460 | 79482..79631 | - | 150 | Protein_88 | hypothetical protein | - |
| CR534_RS00465 | 79628..80005 | - | 378 | WP_000854821.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
| CR534_RS00470 | 80095..80463 | - | 369 | WP_101981452.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CR534_RS00475 | 80543..80764 | - | 222 | Protein_91 | DUF987 domain-containing protein | - |
| CR534_RS00480 | 80851..81327 | - | 477 | WP_004025728.1 | RadC family protein | - |
| CR534_RS29200 | 81343..81516 | - | 174 | Protein_93 | antirestriction protein | - |
| CR534_RS29205 | 81502..81714 | - | 213 | Protein_94 | IS66 family transposase | - |
| CR534_RS00490 | 81745..82095 | - | 351 | WP_000624718.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| CR534_RS00495 | 82092..82517 | - | 426 | WP_000422741.1 | IS66 family insertion sequence hypothetical protein | - |
| CR534_RS29210 | 82579..82938 | + | 360 | Protein_97 | transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13930.95 Da Isoelectric Point: 8.5163
>T86779 WP_000854821.1 NZ_CP024127:c80005-79628 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T86779 NZ_CP024127:c80005-79628 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13664.53 Da Isoelectric Point: 6.0601
>AT86779 WP_101981452.1 NZ_CP024127:c80463-80095 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRACIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADILGSCGYVYMAVYPTPETKK
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRACIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADILGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT86779 NZ_CP024127:c80463-80095 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCTGTATTAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACATCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCTGTATTAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACATCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|