Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1477597..1478271 Replicon chromosome
Accession NZ_CP024126
Organism Streptococcus suis strain HA0609

Toxin (Protein)


Gene name hicA Uniprot ID A0A123U128
Locus tag CR542_RS07555 Protein ID WP_009910449.1
Coordinates 1478089..1478271 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Y6VEQ2
Locus tag CR542_RS07550 Protein ID WP_009910448.1
Coordinates 1477597..1478049 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR542_RS07520 1473592..1474596 + 1005 WP_009910438.1 lactonase family protein -
CR542_RS07525 1474660..1474845 + 186 WP_002935693.1 hypothetical protein -
CR542_RS07530 1474878..1475519 - 642 WP_002935700.1 HAD family hydrolase -
CR542_RS07535 1475686..1475946 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin -
CR542_RS07540 1475948..1476169 - 222 WP_012775256.1 hypothetical protein -
CR542_RS07545 1477276..1477485 - 210 WP_009910447.1 hypothetical protein -
CR542_RS07550 1477597..1478049 - 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CR542_RS07555 1478089..1478271 - 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin Toxin
CR542_RS07560 1478455..1478841 - 387 WP_009910450.1 hypothetical protein -
CR542_RS07565 1478981..1479481 - 501 WP_024409209.1 hypothetical protein -
CR542_RS07570 1479551..1479991 - 441 WP_024409208.1 hypothetical protein -
CR542_RS07575 1480459..1481304 - 846 WP_024409207.1 ATP-binding protein -
CR542_RS07580 1481320..1482114 - 795 WP_079269917.1 DnaD domain protein -
CR542_RS07585 1482128..1482343 - 216 WP_024409205.1 hypothetical protein -
CR542_RS11665 1482348..1482506 - 159 WP_162841287.1 hypothetical protein -
CR542_RS07590 1482517..1482783 - 267 WP_024409204.1 hypothetical protein -
CR542_RS07595 1482794..1482997 - 204 WP_024409203.1 hypothetical protein -
CR542_RS07600 1482990..1483193 - 204 WP_024409202.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1474660..1485775 11115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6681.93 Da        Isoelectric Point: 10.8207

>T86777 WP_009910449.1 NZ_CP024126:c1478271-1478089 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKVGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T86777 NZ_CP024126:c1478271-1478089 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACTAAAGGTGGTAAGGGGTCTCA
CGTTAAACTTGAAAAAGTAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16672.68 Da        Isoelectric Point: 4.0098

>AT86777 WP_009910448.1 NZ_CP024126:c1478049-1477597 [Streptococcus suis]
MLVTYPALFYYDDTDGATAPYFVTFPDFEHSATQGEDMADAMAMASDWLGIHLADYIENGRDIPTPTPINALSLADNNPF
RDDKDIELVYDPSKSFVSMVMVDVAEYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 453 bp

>AT86777 NZ_CP024126:c1478049-1477597 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTACCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAGGGCGAAGATATGGCAGACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGTGATATTCCCACTCCTACCCCTATTAACGCTTTATCATTGGCTGATAATAACCCTTTC
CGTGATGATAAGGACATAGAGCTAGTTTATGACCCTAGCAAGTCTTTTGTATCTATGGTTATGGTTGACGTTGCTGAGTA
TCTAGGCAGTCAAGAGCCTGTAAAGAAAACACTAACTATTCCACGTTGGGCGGATACTTTAGGGCGTGAGTTAGGGCTAA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A123U128

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y6VEQ2

References