Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1475686..1476169 Replicon chromosome
Accession NZ_CP024126
Organism Streptococcus suis strain HA0609

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag CR542_RS07535 Protein ID WP_009910443.1
Coordinates 1475686..1475946 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag CR542_RS07540 Protein ID WP_012775256.1
Coordinates 1475948..1476169 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR542_RS07510 1471071..1472300 - 1230 WP_009910437.1 tetratricopeptide repeat protein -
CR542_RS07515 1472290..1473456 - 1167 WP_002935690.1 AI-2E family transporter -
CR542_RS07520 1473592..1474596 + 1005 WP_009910438.1 lactonase family protein -
CR542_RS07525 1474660..1474845 + 186 WP_002935693.1 hypothetical protein -
CR542_RS07530 1474878..1475519 - 642 WP_002935700.1 HAD family hydrolase -
CR542_RS07535 1475686..1475946 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CR542_RS07540 1475948..1476169 - 222 WP_012775256.1 hypothetical protein Antitoxin
CR542_RS07545 1477276..1477485 - 210 WP_009910447.1 hypothetical protein -
CR542_RS07550 1477597..1478049 - 453 WP_009910448.1 type II toxin-antitoxin system HicB family antitoxin -
CR542_RS07555 1478089..1478271 - 183 WP_009910449.1 type II toxin-antitoxin system HicA family toxin -
CR542_RS07560 1478455..1478841 - 387 WP_009910450.1 hypothetical protein -
CR542_RS07565 1478981..1479481 - 501 WP_024409209.1 hypothetical protein -
CR542_RS07570 1479551..1479991 - 441 WP_024409208.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1474660..1485775 11115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T86776 WP_009910443.1 NZ_CP024126:c1475946-1475686 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T86776 NZ_CP024126:c1475946-1475686 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT86776 WP_012775256.1 NZ_CP024126:c1476169-1475948 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT86776 NZ_CP024126:c1476169-1475948 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References