Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 1475686..1476169 | Replicon | chromosome |
Accession | NZ_CP024126 | ||
Organism | Streptococcus suis strain HA0609 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0Z8BIZ7 |
Locus tag | CR542_RS07535 | Protein ID | WP_009910443.1 |
Coordinates | 1475686..1475946 (-) | Length | 87 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A0Z8BIX7 |
Locus tag | CR542_RS07540 | Protein ID | WP_012775256.1 |
Coordinates | 1475948..1476169 (-) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CR542_RS07510 | 1471071..1472300 | - | 1230 | WP_009910437.1 | tetratricopeptide repeat protein | - |
CR542_RS07515 | 1472290..1473456 | - | 1167 | WP_002935690.1 | AI-2E family transporter | - |
CR542_RS07520 | 1473592..1474596 | + | 1005 | WP_009910438.1 | lactonase family protein | - |
CR542_RS07525 | 1474660..1474845 | + | 186 | WP_002935693.1 | hypothetical protein | - |
CR542_RS07530 | 1474878..1475519 | - | 642 | WP_002935700.1 | HAD family hydrolase | - |
CR542_RS07535 | 1475686..1475946 | - | 261 | WP_009910443.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
CR542_RS07540 | 1475948..1476169 | - | 222 | WP_012775256.1 | hypothetical protein | Antitoxin |
CR542_RS07545 | 1477276..1477485 | - | 210 | WP_009910447.1 | hypothetical protein | - |
CR542_RS07550 | 1477597..1478049 | - | 453 | WP_009910448.1 | type II toxin-antitoxin system HicB family antitoxin | - |
CR542_RS07555 | 1478089..1478271 | - | 183 | WP_009910449.1 | type II toxin-antitoxin system HicA family toxin | - |
CR542_RS07560 | 1478455..1478841 | - | 387 | WP_009910450.1 | hypothetical protein | - |
CR542_RS07565 | 1478981..1479481 | - | 501 | WP_024409209.1 | hypothetical protein | - |
CR542_RS07570 | 1479551..1479991 | - | 441 | WP_024409208.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1474660..1485775 | 11115 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10270.78 Da Isoelectric Point: 9.6925
>T86776 WP_009910443.1 NZ_CP024126:c1475946-1475686 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY
Download Length: 261 bp
>T86776 NZ_CP024126:c1475946-1475686 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8566.55 Da Isoelectric Point: 4.4791
>AT86776 WP_012775256.1 NZ_CP024126:c1476169-1475948 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL
Download Length: 222 bp
>AT86776 NZ_CP024126:c1476169-1475948 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Z8BIZ7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Z8BIX7 |