Detailed information of TA system TA086774

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1088409..1089679
• Replicon: chromosome
• Accession: NZ_CP024126
• Organism: Streptococcus suis strain HA0609

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A0Z8INM2
• Locus tag: CR542_RS05605
• Protein ID: WP_024409332.1
• Coordinates: 1088409..1089203 (-)
• Length: 265 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: CR542_RS05610
• Protein ID: WP_024409333.1
• Coordinates: 1089203..1089679 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CR542_RS05585	1083449..1085362	-	1914	WP_053338584.1	ATP-dependent helicase	-
CR542_RS05590	1085359..1087182	-	1824	Protein_1029	AAA family ATPase	-
CR542_RS05595	1087190..1088134	-	945	WP_024409330.1	IS30 family transposase	-
CR542_RS05600	1088225..1088428	-	204	Protein_1031	AAA family ATPase	-
CR542_RS05605	1088409..1089203	-	795	WP_024409332.1	zeta toxin family protein	Toxin
CR542_RS05610	1089203..1089679	-	477	WP_024409333.1	helix-turn-helix domain-containing protein	Antitoxin
CR542_RS05615	1089749..1090033	-	285	WP_024409334.1	hypothetical protein	-
CR542_RS05620	1090077..1090472	-	396	WP_017285409.1	hypothetical protein	-
CR542_RS05625	1090476..1090703	-	228	WP_024409335.1	hypothetical protein	-
CR542_RS05630	1090757..1091845	-	1089	WP_024409336.1	toprim domain-containing protein	-
CR542_RS05635	1091885..1092523	-	639	WP_024409337.1	hypothetical protein	-
CR542_RS05640	1092634..1092924	-	291	WP_024409338.1	hypothetical protein	-
CR542_RS05645	1092939..1093238	-	300	WP_024382151.1	hypothetical protein	-
CR542_RS05650	1093308..1094219	-	912	WP_032505215.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O)	-	1067457..1136341	68884

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 265 a.a.
• Molecular weight: 30360.57 Da
• Isoelectric Point: 6.6151

>T86774 WP_024409332.1 NZ_CP024126:c1089203-1088409 [Streptococcus suis]
MRLEEFSKDDFDLALKRTIRSLTRGKTTSVTPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLTLQE
EYGKDSVDYTKGFAGKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKARGYQVSLALIATKPELSYLSTLIRYEE
VYVVNPNQARATPKEHHDGIVNHLVDNLRELENDHLFDYIQIYQRDRSCVYDSETDDGSAAEVLQECLFGKWSKVEEEMM
KMGQELLMEFLEMKKGRIYENKKN

Nucleotide

• Length: 795 bp

>T86774 NZ_CP024126:c1089203-1088409 [Streptococcus suis]
ATGCGGTTAGAAGAATTTAGCAAAGATGACTTTGACTTAGCCTTAAAACGAACTATTCGTTCCTTAACTCGTGGTAAAAC
GACATCAGTTACCCCAAAAGCCATCTTACTTGGTGGGCAAAGTGGAGCAGGAAAAACAACGATACACCGTATCAAGCAGA
AAGAGTTCCAAGGTAATATTATCATTATTGACGGTGATAGCTACCGCTCTTTACACCCGAATTATCTAACTTTACAAGAA
GAGTACGGGAAGGATAGCGTGGATTATACCAAAGGTTTTGCAGGAAAAATGGTGGAACAGCTTGTGGATGAACTCAGTAA
ACAAGGTTATCATTTGTTAATCGAAGGAACTTTGAGAACGACAGAAGTCCCACGAAAAACAGCACGGCTATTGAAAGCGA
GAGGTTATCAAGTCTCATTAGCTTTGATAGCAACCAAGCCTGAATTGTCTTATCTCAGCACCTTAATCCGCTACGAAGAA
GTCTATGTGGTTAATCCAAACCAAGCTAGAGCAACTCCTAAAGAACATCATGATGGAATTGTCAATCACTTGGTTGATAA
CTTACGAGAGCTAGAAAACGACCATCTCTTTGATTATATTCAAATTTATCAAAGAGATAGAAGTTGTGTTTATGATTCGG
AAACTGATGACGGTTCAGCAGCAGAAGTGCTACAAGAATGCCTCTTCGGAAAATGGAGCAAGGTGGAGGAAGAGATGATG
AAGATGGGACAGGAATTGTTGATGGAGTTTTTGGAAATGAAAAAAGGTAGAATTTATGAAAATAAAAAAAATTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18119.46 Da
• Isoelectric Point: 4.3193

>AT86774 WP_024409333.1 NZ_CP024126:c1089679-1089203 [Streptococcus suis]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSLSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSELYRYQDSQGITFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELANHQVVA

Nucleotide

• Length: 477 bp

>AT86774 NZ_CP024126:c1089679-1089203 [Streptococcus suis]
ATGATTGGAGATAATATTAAATCGTTACGTAAAACCCATGATTTAACACAACCAGAATTCGCAAAGATTGTTGGAATTTC
TCGAAATAGTTTGAGCCGTTATGAAAATGGGACAAGCTCGTTATCAACAGAGCTCATAGACCGTATCTGTCAGAAATTTA
ATGTATCATATGTTGATATTGTAGGAGAAGAAAAAATGTTAACACCAGTGGAAGATTATCAATTAACCTTAAAAATTGAA
GTTATCAAAGAGCGTGGCGCAGCGATTTTGTCCGAACTATATCGCTATCAAGATAGTCAAGGAATTACTTTTGATGATGA
GACTAGCCCTTGGATTTTGATGAGTGATGATTTGTCTGATCTTATCAATACCAAGATTTACCTTGTCAATACTTTTGATG
AAGTGGAGCGTTACAATGGTTATTTAGATGGTATTGAGCGAATGTTGGAGCTTGCTAATCATCAGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Z8INM2