Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 508963..509449 Replicon chromosome
Accession NZ_CP024126
Organism Streptococcus suis strain HA0609

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag CR542_RS02760 Protein ID WP_011922754.1
Coordinates 509180..509449 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag CR542_RS02755 Protein ID WP_002938604.1
Coordinates 508963..509190 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR542_RS02725 504295..504840 - 546 WP_009909618.1 NAD(P)H-dependent oxidoreductase -
CR542_RS02730 504903..505352 - 450 WP_009909619.1 MarR family transcriptional regulator -
CR542_RS02735 505655..506152 + 498 WP_002938611.1 DUF5590 domain-containing protein -
CR542_RS02740 506149..507330 + 1182 WP_002938610.1 pyridoxal phosphate-dependent aminotransferase -
CR542_RS02745 507345..508691 + 1347 WP_013730302.1 asparagine--tRNA ligase -
CR542_RS02755 508963..509190 + 228 WP_002938604.1 hypothetical protein Antitoxin
CR542_RS02760 509180..509449 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CR542_RS02770 509855..511174 + 1320 WP_002937278.1 MATE family efflux transporter -
CR542_RS02775 511358..511735 + 378 WP_013730303.1 RidA family protein -
CR542_RS02780 511757..512644 + 888 WP_002937261.1 RNase adapter RapZ -
CR542_RS02785 512641..513615 + 975 WP_002937257.1 YvcK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T86772 WP_011922754.1 NZ_CP024126:509180-509449 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T86772 NZ_CP024126:509180-509449 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT86772 WP_002938604.1 NZ_CP024126:508963-509190 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT86772 NZ_CP024126:508963-509190 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References