Detailed information of TA system TA086770

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3436064..3436743
• Replicon: chromosome
• Accession: NZ_CP024124
• Organism: Acinetobacter baumannii strain AYP-A2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: AYP_RS16635
• Protein ID: WP_000838146.1
• Coordinates: 3436561..3436743 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: AYP_RS16630
• Protein ID: WP_000966688.1
• Coordinates: 3436064..3436468 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYP_RS16620	3435020..3435283	-	264	WP_001275792.1	hypothetical protein	-
AYP_RS16625	3435285..3435965	-	681	WP_000721572.1	hypothetical protein	-
AYP_RS16630	3436064..3436468	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AYP_RS16635	3436561..3436743	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
AYP_RS16645	3437069..3437584	-	516	WP_024616020.1	hypothetical protein	-
AYP_RS16650	3437655..3438572	-	918	WP_000094253.1	hypothetical protein	-
AYP_RS16655	3438625..3439980	-	1356	WP_000002415.1	hypothetical protein	-
AYP_RS16660	3439980..3440333	-	354	WP_000064593.1	hypothetical protein	-
AYP_RS16665	3440430..3440951	-	522	WP_000749909.1	SH3 domain-containing protein	-
AYP_RS16670	3441060..3441278	-	219	WP_001277696.1	hypothetical protein	-
AYP_RS16675	3441280..3441723	-	444	WP_002016455.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3417236..3469409	52173

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T86770 WP_000838146.1 NZ_CP024124:c3436743-3436561 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T86770 NZ_CP024124:c3436743-3436561 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT86770 WP_000966688.1 NZ_CP024124:c3436468-3436064 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT86770 NZ_CP024124:c3436468-3436064 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6