Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2905914..2906565 Replicon chromosome
Accession NZ_CP024124
Organism Acinetobacter baumannii strain AYP-A2

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag AYP_RS14100 Protein ID WP_000838146.1
Coordinates 2906383..2906565 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag AYP_RS14095 Protein ID WP_000966689.1
Coordinates 2905914..2906318 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYP_RS14080 2900947..2901288 - 342 WP_001281459.1 phage tail protein -
AYP_RS14085 2901406..2905371 - 3966 WP_000191304.1 tape measure protein -
AYP_RS14090 2905432..2905833 - 402 WP_000720591.1 hypothetical protein -
AYP_RS14095 2905914..2906318 - 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AYP_RS14100 2906383..2906565 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
AYP_RS14105 2906897..2907430 - 534 WP_001185622.1 hypothetical protein -
AYP_RS14110 2907475..2908404 - 930 WP_000094300.1 hypothetical protein -
AYP_RS14115 2908512..2908724 - 213 WP_000121166.1 hypothetical protein -
AYP_RS14120 2908726..2909124 - 399 WP_001132270.1 hypothetical protein -
AYP_RS14125 2909126..2909494 - 369 WP_000539752.1 hypothetical protein -
AYP_RS14130 2909466..2909870 - 405 WP_000248324.1 hypothetical protein -
AYP_RS14135 2909879..2910247 - 369 WP_000524231.1 hypothetical protein -
AYP_RS14140 2910249..2910638 - 390 WP_000008492.1 hypothetical protein -
AYP_RS14145 2910643..2911308 - 666 WP_000767881.1 stress-responsive nuclear envelope protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2882343..2936958 54615


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T86769 WP_000838146.1 NZ_CP024124:c2906565-2906383 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T86769 NZ_CP024124:c2906565-2906383 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT86769 WP_000966689.1 NZ_CP024124:c2906318-2905914 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT86769 NZ_CP024124:c2906318-2905914 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References