Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 1952831..1953823 Replicon chromosome
Accession NZ_CP024101
Organism Bacillus cytotoxicus strain CH_25

Toxin (Protein)


Gene name spoIISA Uniprot ID A7GPN6
Locus tag CG482_RS10095 Protein ID WP_012094283.1
Coordinates 1952831..1953571 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A7GPN7
Locus tag CG482_RS10100 Protein ID WP_012094285.1
Coordinates 1953695..1953823 (+) Length 43 a.a.

Genomic Context

CG482_RS10065CG482_RS10075CG482_RS10080CG482_RS10085CG482_RS10095CG482_RS10100CG482_RS10105CG482_RS10120CG482_RS10125CG482_RS10070CG482_RS10110CG482_RS10115
Location: 1948305..1949207 (903 bp)
Type: Others
Protein ID: WP_012094278.1
Location: 1949755..1951059 (1305 bp)
Type: Others
Protein ID: WP_012094279.1
Location: 1951279..1951761 (483 bp)
Type: Others
Protein ID: WP_012094281.1
Location: 1951899..1952636 (738 bp)
Type: Others
Protein ID: WP_012094282.1
Location: 1952831..1953571 (741 bp)
Type: Toxin
Protein ID: WP_012094283.1
Location: 1953695..1953823 (129 bp)
Type: Antitoxin
Protein ID: WP_012094285.1
Location: 1953900..1954076 (177 bp)
Type: Others
Protein ID: WP_012094286.1
Location: 1955907..1957376 (1470 bp)
Type: Others
Protein ID: WP_012094289.1
Location: 1957981..1958232 (252 bp)
Type: Others
Protein ID: WP_012094290.1
Location: 1949254..1949560 (307 bp)
Type: Others
Protein ID: Protein_1846
Location: 1954234..1954779 (546 bp)
Type: Others
Protein ID: WP_012094287.1
Location: 1954820..1955701 (882 bp)
Type: Others
Protein ID: WP_012094288.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CG482_RS100651948305..1949207+903WP_012094278.1ATPase-
CG482_RS100701949254..1949560-307Protein_1846hypothetical protein-
CG482_RS100751949755..1951059+1305WP_012094279.1DEAD/DEAH box helicase-
CG482_RS100801951279..1951761+483WP_012094281.1MarR family winged helix-turn-helix transcriptional regulator-
CG482_RS100851951899..1952636+738WP_012094282.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
CG482_RS100951952831..1953571+741WP_012094283.1type II toxin-antitoxin system SpoIISA family toxinToxin
CG482_RS101001953695..1953823+129WP_012094285.1hypothetical proteinAntitoxin
CG482_RS101051953900..1954076+177WP_012094286.1hypothetical protein-
CG482_RS101101954234..1954779-546WP_012094287.1GNAT family N-acetyltransferase-
CG482_RS101151954820..1955701-882WP_012094288.1aminoglycoside 6-adenylyltransferase-
CG482_RS101201955907..1957376+1470WP_012094289.1aminoacyl-histidine dipeptidase-
CG482_RS101251957981..1958232+252WP_012094290.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28628.30 Da        Isoelectric Point: 6.7302

>T86725 WP_012094283.1 NZ_CP024101:1952831-1953571 [Bacillus cytotoxicus]
MTVTSVRIGLFFLVIFFLFLIFFYWRNEERYEERKQLIRKTWYGLFITSVTMYFMMKGIDLTLWKHILMVVAMVVFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTLIQNVNPAAFGTMEWETDAEYARSLNAFLDTYAEKIGAK
IVVFVTEEELNTNFRGVRSQFSITVSPESIEQLNEQKAVQIENVGIIPAKIIKDVYIIMDGQKNNLQDRDFENVYNLTIH
HSYFCK

Download         Length: 741 bp

>T86725 NZ_CP024101:1952831-1953571 [Bacillus cytotoxicus]
TTGACTGTCACTAGCGTTCGAATTGGCTTGTTTTTTCTTGTAATCTTTTTTTTATTTCTTATTTTCTTTTATTGGAGAAA
TGAAGAACGATACGAGGAAAGAAAACAACTTATTCGAAAGACGTGGTATGGTTTATTTATTACATCAGTCACAATGTATT
TCATGATGAAAGGAATTGATTTAACCCTCTGGAAACATATTTTAATGGTTGTTGCGATGGTTGTATTTGTTGATATTGCA
TTTATTTTAACGCCAAATATTTCGGAAATCTGGGGCGCAAAGTTTAGTGATATTGGTAAGACAGTTCAATCGATTAAACG
ATCGCTTATTGCTTCAAAAGCAAGAGGAGAAATATATACAACACTTATTCAAAATGTAAATCCAGCTGCATTTGGTACGA
TGGAATGGGAAACAGATGCTGAGTATGCACGCAGTTTAAATGCTTTTCTTGATACGTATGCTGAAAAAATAGGTGCGAAA
ATTGTAGTATTTGTCACAGAAGAGGAATTAAATACAAACTTCCGAGGTGTTCGATCTCAATTTAGTATTACAGTATCACC
CGAATCTATTGAACAACTGAATGAGCAAAAAGCAGTTCAAATTGAAAATGTTGGAATTATACCAGCGAAAATAATAAAAG
ACGTTTATATTATTATGGATGGACAAAAAAATAATTTGCAAGATCGTGACTTTGAAAATGTATATAATTTAACAATACAT
CATAGTTACTTTTGTAAGTAA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4984.43 Da        Isoelectric Point: 3.9944

>AT86725 WP_012094285.1 NZ_CP024101:1953695-1953823 [Bacillus cytotoxicus]
VLKEYSNDFFKDEAEDTTDFSLIKGDTMQQVEELEEELKRRG

Download         Length: 129 bp

>AT86725 NZ_CP024101:1953695-1953823 [Bacillus cytotoxicus]
GTGTTAAAAGAATATAGCAATGATTTCTTTAAAGACGAAGCTGAGGATACAACAGATTTTTCTTTAATAAAAGGAGATAC
AATGCAGCAAGTGGAAGAATTAGAAGAAGAATTGAAAAGAAGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA7GPN6

Antitoxin

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Source
ID
Structure
AlphaFold DBA7GPN7

References