Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2268974..2269500 Replicon chromosome
Accession NZ_CP024090
Organism Escherichia coli strain WG5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CSR56_RS11560 Protein ID WP_047402633.1
Coordinates 2269213..2269500 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag CSR56_RS11555 Protein ID WP_000534858.1
Coordinates 2268974..2269213 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSR56_RS23665 2264078..2264365 + 288 Protein_2108 hypothetical protein -
CSR56_RS11535 2266359..2267672 + 1314 WP_000589005.1 ISNCY family transposase -
CSR56_RS11545 2268109..2268441 - 333 WP_001301033.1 protein FlxA -
CSR56_RS11550 2268644..2268949 - 306 WP_001326990.1 hypothetical protein -
CSR56_RS11555 2268974..2269213 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
CSR56_RS11560 2269213..2269500 + 288 WP_047402633.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
CSR56_RS11565 2269572..2269727 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
CSR56_RS11570 2269944..2270195 + 252 WP_000980994.1 hypothetical protein -
CSR56_RS11575 2270262..2270540 + 279 WP_012304870.1 hypothetical protein -
CSR56_RS11580 2270542..2271591 + 1050 WP_001265199.1 DUF968 domain-containing protein -
CSR56_RS11585 2271605..2272357 + 753 WP_001047135.1 antitermination protein -
CSR56_RS23455 2272635..2272724 - 90 WP_120795389.1 hypothetical protein -
CSR56_RS11590 2272779..2272991 - 213 WP_000087756.1 cold shock-like protein CspF -
CSR56_RS11595 2273292..2273507 + 216 WP_000066484.1 cold shock-like protein CspB -
CSR56_RS23770 2273871..2274041 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
CSR56_RS11600 2274261..2274476 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2256756..2290997 34241


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11224.28 Da        Isoelectric Point: 10.4221

>T86703 WP_047402633.1 NZ_CP024090:2269213-2269500 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLKSPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T86703 NZ_CP024090:2269213-2269500 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTAAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT86703 WP_000534858.1 NZ_CP024090:2268974-2269213 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT86703 NZ_CP024090:2268974-2269213 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References