Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 371596..372134 Replicon chromosome
Accession NZ_CP024083
Organism Vibrio cholerae strain FORC_073

Toxin (Protein)


Gene name parE Uniprot ID A0A3Q0L5T8
Locus tag FORC73_RS16355 Protein ID WP_001247271.1
Coordinates 371596..371895 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7Z7YFC5
Locus tag FORC73_RS16360 Protein ID WP_001107716.1
Coordinates 371892..372134 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC73_RS16325 367469..368122 + 654 WP_113612641.1 hypothetical protein -
FORC73_RS16330 368157..368794 - 638 Protein_354 IS30 family transposase -
FORC73_RS16335 368862..370039 + 1178 WP_162906056.1 IS3 family transposase -
FORC73_RS16340 370047..370376 - 330 Protein_356 IS30 family transposase -
FORC73_RS16345 370617..371114 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
FORC73_RS16350 371111..371383 - 273 WP_000246253.1 DUF1778 domain-containing protein -
FORC73_RS16355 371596..371895 - 300 WP_001247271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC73_RS16360 371892..372134 - 243 WP_001107716.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FORC73_RS16365 372723..375509 + 2787 WP_001966133.1 alkaline phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 308518..372134 63616
- inside Integron - - 309195..371895 62700


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11703.39 Da        Isoelectric Point: 9.9572

>T86678 WP_001247271.1 NZ_CP024083:c371895-371596 [Vibrio cholerae]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T86678 NZ_CP024083:c371895-371596 [Vibrio cholerae]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAATCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATAGAGATTATCCGTATCCTCCACAAAAGCATGGATGTGAATCCAATTTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8895.84 Da        Isoelectric Point: 4.2950

>AT86678 WP_001107716.1 NZ_CP024083:c372134-371892 [Vibrio cholerae]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVAGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT86678 NZ_CP024083:c372134-371892 [Vibrio cholerae]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGCCGCTATGG
CTCTGCAAGTGAAGTTATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTGTTGCGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAAAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T8

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z7YFC5

References