Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 335880..336408 | Replicon | chromosome |
| Accession | NZ_CP024083 | ||
| Organism | Vibrio cholerae strain FORC_073 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | FORC73_RS15935 | Protein ID | WP_000221351.1 |
| Coordinates | 335880..336170 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | H9L4T4 |
| Locus tag | FORC73_RS15940 | Protein ID | WP_000213183.1 |
| Coordinates | 336160..336408 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC73_RS15860 | 330893..331717 | + | 825 | WP_153734389.1 | hypothetical protein | - |
| FORC73_RS15865 | 331714..331836 | + | 123 | WP_119783597.1 | DUF3265 domain-containing protein | - |
| FORC73_RS15870 | 332024..332203 | + | 180 | WP_000887876.1 | DUF645 family protein | - |
| FORC73_RS15875 | 332352..332714 | + | 363 | WP_161418255.1 | DUF4144 domain-containing protein | - |
| FORC73_RS15890 | 333034..333204 | + | 171 | WP_001928536.1 | DUF645 family protein | - |
| FORC73_RS15900 | 333405..333701 | + | 297 | WP_000617998.1 | Dabb family protein | - |
| FORC73_RS15905 | 333953..334507 | + | 555 | WP_162923449.1 | hypothetical protein | - |
| FORC73_RS15915 | 334843..335022 | + | 180 | WP_119783480.1 | DUF645 family protein | - |
| FORC73_RS15930 | 335312..335737 | + | 426 | WP_001898239.1 | hypothetical protein | - |
| FORC73_RS15935 | 335880..336170 | - | 291 | WP_000221351.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC73_RS15940 | 336160..336408 | - | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FORC73_RS15945 | 336609..336905 | + | 297 | WP_000617997.1 | Dabb family protein | - |
| FORC73_RS15950 | 337013..337541 | + | 529 | Protein_301 | GNAT family N-acetyltransferase | - |
| FORC73_RS15955 | 337701..338114 | + | 414 | WP_119783481.1 | GNAT family N-acetyltransferase | - |
| FORC73_RS15960 | 338269..338586 | - | 318 | WP_162923450.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FORC73_RS15965 | 338605..338847 | - | 243 | WP_000557291.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FORC73_RS15970 | 339126..339356 | - | 231 | WP_000838533.1 | PAS factor family protein | - |
| FORC73_RS15975 | 339575..340009 | + | 435 | WP_000256035.1 | GNAT family N-acetyltransferase | - |
| FORC73_RS15980 | 340081..340164 | + | 84 | WP_119783483.1 | iron transporter | - |
| FORC73_RS15985 | 340179..340574 | + | 396 | WP_000870865.1 | DUF3465 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 308518..372134 | 63616 | |
| - | inside | Integron | - | - | 309195..371895 | 62700 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11220.12 Da Isoelectric Point: 10.1443
>T86672 WP_000221351.1 NZ_CP024083:c336170-335880 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYEIKLQQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYEIKLQQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
Download Length: 291 bp
>T86672 NZ_CP024083:c336170-335880 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATGAAATAA
AACTTCAGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATGAAATAA
AACTTCAGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8937.28 Da Isoelectric Point: 4.1079
>AT86672 WP_000213183.1 NZ_CP024083:c336408-336160 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
Download Length: 249 bp
>AT86672 NZ_CP024083:c336408-336160 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGCGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGCGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|