Detailed information of TA system TA086670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2214245..2214773
• Replicon: chromosome
• Accession: NZ_CP024082
• Organism: Vibrio cholerae strain FORC_073

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FORC73_RS10350
• Protein ID: WP_000639510.1
• Coordinates: 2214245..2214535 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FORC73_RS10355
• Protein ID: WP_000213184.1
• Coordinates: 2214525..2214773 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC73_RS10315	2209252..2209728	+	477	WP_000148678.1	DNA repair protein RadC	-
FORC73_RS10320	2209725..2210153	+	429	WP_000634666.1	DUF2787 domain-containing protein	-
FORC73_RS10325	2210204..2210650	+	447	WP_000065403.1	DUF2787 domain-containing protein	-
FORC73_RS10330	2210753..2211739	+	987	WP_002044218.1	GTPase family protein	-
FORC73_RS10335	2211774..2212415	-	642	WP_080284354.1	inovirus Gp2 family protein	-
FORC73_RS10340	2212853..2213860	+	1008	WP_032475262.1	CopG family transcriptional regulator	-
FORC73_RS10345	2213953..2214153	-	201	WP_032475261.1	AlpA family transcriptional regulator	-
FORC73_RS10350	2214245..2214535	-	291	WP_000639510.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FORC73_RS10355	2214525..2214773	-	249	WP_000213184.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FORC73_RS10360	2214967..2216337	-	1371	WP_032475260.1	Fic family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hcp-2 / vgrG-2	2185367..2222905	37538

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11113.97 Da
• Isoelectric Point: 10.5016

>T86670 WP_000639510.1 NZ_CP024082:c2214535-2214245 [Vibrio cholerae]
MIYKLSFKKSALKEWQKLGATLQQQFKKKLAERLENPHVPASKLSGADNVYKIKLRQSGYRLVYNVEDDVVIVTVLAVGK
RERSDVYRKAMTRLDD

Nucleotide

• Length: 291 bp

>T86670 NZ_CP024082:c2214535-2214245 [Vibrio cholerae]
ATGATCTATAAGCTCAGTTTCAAAAAGAGTGCGCTTAAAGAATGGCAGAAGCTGGGCGCTACGCTGCAACAGCAGTTTAA
GAAAAAACTGGCGGAGCGGCTAGAGAATCCCCACGTTCCCGCTTCTAAGCTCTCTGGCGCTGACAATGTTTACAAAATCA
AGCTGCGCCAGTCTGGATACCGTTTGGTTTACAATGTGGAAGATGACGTCGTTATTGTCACTGTGTTAGCGGTAGGTAAG
CGTGAGCGCAGCGATGTTTACCGTAAAGCGATGACGCGGTTAGATGACTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9130.40 Da
• Isoelectric Point: 3.9610

>AT86670 WP_000213184.1 NZ_CP024082:c2214773-2214525 [Vibrio cholerae]
MTTRILADVAASITELKANPMKVANSAYGEPVAVLNRNEPVFYCVPAEAYELMMDRLEDLELLAIARERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT86670 NZ_CP024082:c2214773-2214525 [Vibrio cholerae]
ATGACCACTAGAATTTTGGCTGATGTGGCTGCCAGTATCACTGAACTTAAAGCGAACCCGATGAAAGTAGCGAATAGTGC
TTATGGCGAGCCTGTTGCCGTGCTAAACCGCAATGAGCCCGTGTTTTACTGTGTGCCTGCTGAAGCGTATGAGTTGATGA
TGGACCGACTTGAAGATCTTGAGTTACTGGCCATTGCGAGAGAGCGTGAGTCAGAAGAAAGCATCTCGGTAAATATTGAT
GATCTATAA