Detailed information of TA system TA086666

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 631979..632657
• Replicon: chromosome
• Accession: NZ_CP024076
• Organism: Helicobacter pylori strain 7.13_R2c

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BXP04_RS03170
• Protein ID: WP_080006198.1
• Coordinates: 632334..632657 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D7FDF9
• Locus tag: BXP04_RS03165
• Protein ID: WP_001134161.1
• Coordinates: 631979..632353 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BXP04_RS03140	627486..627883	+	398	Protein_583	hypothetical protein	-
BXP04_RS03155	628789..631029	+	2241	WP_104937578.1	Hop family adhesin BabA	-
BXP04_RS03165	631979..632353	+	375	WP_001134161.1	hypothetical protein	Antitoxin
BXP04_RS03170	632334..632657	+	324	WP_080006198.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
BXP04_RS03175	632702..633226	-	525	WP_001135637.1	acyl-CoA thioesterase	-
BXP04_RS03180	633366..634214	+	849	WP_000504111.1	SDR family oxidoreductase	-
BXP04_RS03185	634207..635187	+	981	WP_000921449.1	iron ABC transporter permease	-
BXP04_RS03190	635187..635954	+	768	WP_000242349.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12475.74 Da
• Isoelectric Point: 9.5268

>T86666 WP_080006198.1 NZ_CP024076:632334-632657 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILRKKEPLDPQFQDHALKGKWKPYRECHIKPDILLVYLVKDDELILLRLG
SHSELFCKSPTQFITLKPTAQPTTPLF

Nucleotide

• Length: 324 bp

>T86666 NZ_CP024076:632334-632657 [Helicobacter pylori]
GTGTTGAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAAGGAAGTCATTCTAAGAAAGAAAGAACCGCTAGATCCACAATTTCAAGATCATGCCCTAAAAGGCAAGTGGAAGCCTT
ATAGAGAATGCCACATTAAGCCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAACTGATTTTGTTAAGGTTAGGC
AGTCATAGCGAGCTGTTTTGTAAATCACCCACACAATTTATAACGCTTAAACCAACCGCTCAACCAACTACCCCCCTTTT
TTAG

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14713.64 Da
• Isoelectric Point: 7.8113

>AT86666 WP_001134161.1 NZ_CP024076:631979-632353 [Helicobacter pylori]
MPNTTNKDYTQYSEKQLFNLIHQLEQKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCLG
RKIPNIQTQQAMRDVYNKETDLIVEDFSSYSDERKKALGVETQS

Nucleotide

• Length: 375 bp

>AT86666 NZ_CP024076:631979-632353 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGATTACACCCAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCAAAA
AATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACTTTA
AGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTGTTTGGGG
CGCAAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGTGTATAACAAAGAAACAGATTTGATTGTTGAGGATTT
TTCTAGTTACAGCGATGAGAGAAAAAAGGCTTTGGGTGTTGAAACTCAATCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2L2I1T1