Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 724096..724582 Replicon chromosome
Accession NZ_CP024050
Organism Streptococcus suis strain CS100322

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag CR541_RS03770 Protein ID WP_011922754.1
Coordinates 724313..724582 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag CR541_RS03765 Protein ID WP_002938604.1
Coordinates 724096..724323 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR541_RS03735 719139..719588 - 450 WP_009909619.1 MarR family transcriptional regulator -
CR541_RS03740 719882..720729 + 848 WP_087892711.1 IS630 family transposase -
CR541_RS03745 720788..721285 + 498 WP_011922751.1 DUF5590 domain-containing protein -
CR541_RS03750 721282..722463 + 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
CR541_RS03755 722478..723824 + 1347 WP_011922752.1 asparagine--tRNA ligase -
CR541_RS03765 724096..724323 + 228 WP_002938604.1 hypothetical protein Antitoxin
CR541_RS03770 724313..724582 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CR541_RS03780 724988..726307 + 1320 WP_012775027.1 MATE family efflux transporter -
CR541_RS03785 726358..726735 + 378 WP_002937263.1 RidA family protein -
CR541_RS03790 726757..727644 + 888 WP_011922160.1 RNase adapter RapZ -
CR541_RS03795 727641..728615 + 975 WP_002937257.1 YvcK family protein -
CR541_RS03800 728612..729529 + 918 WP_002937252.1 DNA-binding protein WhiA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) / tet(40) cpsI 655378..739960 84582


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T86624 WP_011922754.1 NZ_CP024050:724313-724582 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T86624 NZ_CP024050:724313-724582 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT86624 WP_002938604.1 NZ_CP024050:724096-724323 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT86624 NZ_CP024050:724096-724323 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References