Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2208609..2209125 Replicon chromosome
Accession NZ_CP024038
Organism Klebsiella pneumoniae strain QS17-0029

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag CR230_RS11115 Protein ID WP_002886902.1
Coordinates 2208841..2209125 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CR230_RS11110 Protein ID WP_002886901.1
Coordinates 2208609..2208851 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR230_RS11095 2204637..2205377 + 741 WP_002886899.1 KDGP aldolase family protein -
CR230_RS11100 2205444..2206598 + 1155 WP_023302389.1 lactonase family protein -
CR230_RS11105 2206621..2208531 + 1911 WP_009486549.1 BglG family transcription antiterminator -
CR230_RS11110 2208609..2208851 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CR230_RS11115 2208841..2209125 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CR230_RS11120 2209129..2209593 - 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CR230_RS11125 2209902..2212040 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
CR230_RS11130 2212397..2213140 - 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
CR230_RS29275 2213143..2213316 - 174 WP_032410138.1 hypothetical protein -
CR230_RS11135 2213401..2213709 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T86601 WP_002886902.1 NZ_CP024038:2208841-2209125 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T86601 NZ_CP024038:2208841-2209125 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT86601 WP_002886901.1 NZ_CP024038:2208609-2208851 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT86601 NZ_CP024038:2208609-2208851 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References