Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 866202..866859 Replicon chromosome
Accession NZ_CP024038
Organism Klebsiella pneumoniae strain QS17-0029

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag CR230_RS04305 Protein ID WP_002916310.1
Coordinates 866202..866612 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CR230_RS04310 Protein ID WP_002916312.1
Coordinates 866593..866859 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR230_RS04285 862202..863935 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
CR230_RS04290 863941..864654 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CR230_RS04295 864677..865573 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CR230_RS04300 865674..866195 + 522 WP_004144730.1 flavodoxin FldB -
CR230_RS04305 866202..866612 - 411 WP_002916310.1 protein YgfX Toxin
CR230_RS04310 866593..866859 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CR230_RS04315 867105..868088 + 984 WP_004185555.1 tRNA-modifying protein YgfZ -
CR230_RS04320 868239..868898 - 660 WP_002916317.1 hemolysin III family protein -
CR230_RS04325 869062..869373 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
CR230_RS04330 869423..870151 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
CR230_RS04335 870270..871703 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T86596 WP_002916310.1 NZ_CP024038:c866612-866202 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T86596 NZ_CP024038:c866612-866202 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT86596 WP_002916312.1 NZ_CP024038:c866859-866593 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT86596 NZ_CP024038:c866859-866593 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References