Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4407302..4407957 Replicon chromosome
Accession NZ_CP024025
Organism Pseudomonas protegens strain DTU9.1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CLA18_RS19940 Protein ID WP_210458472.1
Coordinates 4407302..4407481 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CLA18_RS19945 Protein ID WP_053159226.1
Coordinates 4407532..4407957 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLA18_RS19910 (CLA18_19835) 4402700..4402975 + 276 WP_011061856.1 peptidylprolyl isomerase -
CLA18_RS19915 (CLA18_19840) 4403035..4403943 - 909 WP_265577199.1 sugar kinase -
CLA18_RS19920 (CLA18_19845) 4404193..4405410 - 1218 WP_265577200.1 amino acid deaminase -
CLA18_RS19925 (CLA18_19850) 4405458..4406222 - 765 WP_265577201.1 IclR family transcriptional regulator -
CLA18_RS19930 (CLA18_19855) 4406356..4406745 - 390 WP_011061860.1 RidA family protein -
CLA18_RS19935 4407064..4407213 + 150 WP_155494419.1 hypothetical protein -
CLA18_RS19940 (CLA18_19860) 4407302..4407481 + 180 WP_210458472.1 type II toxin-antitoxin system HicA family toxin Toxin
CLA18_RS19945 (CLA18_19865) 4407532..4407957 + 426 WP_053159226.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CLA18_RS19950 (CLA18_19870) 4408045..4408590 - 546 WP_210458471.1 hypothetical protein -
CLA18_RS19955 4408637..4408816 - 180 WP_123725200.1 hypothetical protein -
CLA18_RS19960 (CLA18_19875) 4408952..4410385 - 1434 WP_265577202.1 RtcB family protein -
CLA18_RS19965 (CLA18_19880) 4410893..4411909 - 1017 WP_210483800.1 fimbrial protein -
CLA18_RS19970 (CLA18_19885) 4412217..4412789 + 573 WP_265577203.1 type 1 glutamine amidotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6604.62 Da        Isoelectric Point: 10.9062

>T86588 WP_210458472.1 NZ_CP024025:4407302-4407481 [Pseudomonas protegens]
MKFSEFRQWLKAQGVVFEAGKGSHFKVTAPNGNKTTFADHGSKEMPEPTRKAIIRQLGL

Download         Length: 180 bp

>T86588 NZ_CP024025:4407302-4407481 [Pseudomonas protegens]
ATGAAATTCAGCGAATTCAGACAGTGGTTGAAAGCTCAAGGCGTGGTCTTCGAGGCCGGTAAAGGCAGCCACTTCAAAGT
CACGGCCCCAAACGGCAACAAGACCACCTTCGCGGATCACGGCAGCAAGGAAATGCCCGAACCCACCCGCAAGGCAATCA
TCAGGCAATTGGGGCTCTAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15743.06 Da        Isoelectric Point: 4.7790

>AT86588 WP_053159226.1 NZ_CP024025:4407532-4407957 [Pseudomonas protegens]
MYDYAIRFEQDRAPGVAVFCRDLPELNSFGDDPEHAINQAIDALETTLSLYVDQRRAIPPASEPLPGEQVIHLPMVTVAK
IALWNTMMERDMRKADLCRLLGIHQAQGDRLVDFLHSSKMEQLENALAALGKRLAVSVEAA

Download         Length: 426 bp

>AT86588 NZ_CP024025:4407532-4407957 [Pseudomonas protegens]
ATGTACGACTACGCCATTCGCTTCGAGCAAGACCGTGCACCGGGAGTGGCGGTCTTCTGCCGCGATCTGCCCGAACTCAA
TAGCTTTGGCGATGATCCTGAGCACGCCATCAACCAGGCCATCGACGCGCTCGAAACCACGCTGTCCCTTTACGTCGACC
AGCGCCGCGCCATTCCCCCAGCCTCTGAGCCGCTACCAGGGGAACAGGTCATTCATTTGCCAATGGTGACCGTGGCCAAG
ATAGCGCTGTGGAACACGATGATGGAGCGGGACATGCGCAAGGCCGATCTATGCCGACTGCTCGGAATCCACCAGGCCCA
GGGAGATCGCCTGGTGGACTTTCTACACAGCTCCAAAATGGAACAGCTGGAAAATGCCCTCGCAGCCCTAGGTAAACGTC
TTGCAGTATCAGTGGAGGCGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References