Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 983729..984325 Replicon chromosome
Accession NZ_CP024025
Organism Pseudomonas protegens strain DTU9.1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CLA18_RS04365 Protein ID WP_210671019.1
Coordinates 984023..984325 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4KIY9
Locus tag CLA18_RS04360 Protein ID WP_011059020.1
Coordinates 983729..984019 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLA18_RS04340 (CLA18_04350) 979999..982131 - 2133 WP_265577784.1 TonB-dependent copper receptor -
CLA18_RS04345 (CLA18_04355) 982220..982630 - 411 WP_065364904.1 DUF2946 domain-containing protein -
CLA18_RS04350 (CLA18_04360) 982686..983180 - 495 WP_065364905.1 copper chaperone PCu(A)C -
CLA18_RS04355 (CLA18_04365) 983230..983628 - 399 WP_210457651.1 DUF2946 domain-containing protein -
CLA18_RS04360 (CLA18_04370) 983729..984019 - 291 WP_011059020.1 putative addiction module antidote protein Antitoxin
CLA18_RS04365 (CLA18_04375) 984023..984325 - 303 WP_210671019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CLA18_RS04370 (CLA18_04380) 984509..985237 - 729 WP_011059022.1 cobalt-precorrin-6A reductase -
CLA18_RS04375 (CLA18_04385) 985234..986331 - 1098 WP_210671021.1 cobalt-precorrin-5B (C(1))-methyltransferase -
CLA18_RS04380 (CLA18_04390) 986425..987639 - 1215 WP_210671023.1 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE -
CLA18_RS04385 (CLA18_04395) 987778..989091 + 1314 WP_265577785.1 precorrin-3B synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(5-97)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11514.38 Da        Isoelectric Point: 10.6512

>T86584 WP_210671019.1 NZ_CP024025:c984325-984023 [Pseudomonas protegens]
MFVFEQTPEFSRWLLNLKDPQGKTRVLARIRAAQLGRFGDCEPVGEGVHEMRIHRGPGYRVYFPRRGKVIYLLLIGGDKA
TQKRDIQRARQLACDLKSEG

Download         Length: 303 bp

>T86584 NZ_CP024025:c984325-984023 [Pseudomonas protegens]
ATGTTCGTTTTCGAGCAGACTCCTGAGTTCAGCCGCTGGCTGCTGAACCTGAAGGACCCGCAAGGGAAAACCCGTGTACT
GGCCAGGATCCGCGCCGCACAGCTGGGCCGTTTTGGCGACTGCGAACCTGTGGGCGAAGGCGTCCACGAGATGCGCATCC
ACCGCGGCCCGGGTTACCGGGTGTACTTCCCGCGCCGCGGCAAAGTGATCTACCTGCTGTTGATCGGCGGCGACAAGGCC
ACCCAGAAACGCGATATCCAACGGGCCAGGCAACTGGCCTGCGACCTCAAGAGCGAGGGCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10423.94 Da        Isoelectric Point: 5.0939

>AT86584 WP_011059020.1 NZ_CP024025:c984019-983729 [Pseudomonas protegens]
MRTPVTRFDAAEYLKTPEDMVAYLDACFEEDTGDGVLIRAALNDIARARGMTQVARDTGLGRESLYKALGSQGNPEFATI
IKVMKALGLKINVSNA

Download         Length: 291 bp

>AT86584 NZ_CP024025:c984019-983729 [Pseudomonas protegens]
ATGCGCACCCCAGTGACCCGCTTCGACGCGGCGGAGTACCTCAAGACCCCTGAAGACATGGTCGCCTACCTCGACGCCTG
CTTCGAGGAAGACACCGGCGACGGCGTGCTGATCCGCGCCGCACTCAACGACATCGCCCGTGCCCGCGGCATGACCCAGG
TCGCCCGTGACACCGGCCTGGGCCGCGAAAGCCTGTACAAGGCCCTCGGCAGCCAGGGCAACCCGGAGTTCGCGACTATC
ATCAAGGTGATGAAGGCCCTGGGGTTGAAGATCAACGTCAGCAACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q4KIY9

References