Detailed information of TA system TA086580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 5065692..5066197
• Replicon: chromosome
• Accession: NZ_CP024024
• Organism: Pseudomonas aeruginosa strain PARM801

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: BBX44_RS23780
• Protein ID: WP_003083773.1
• Coordinates: 5065692..5065973 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: BBX44_RS23785
• Protein ID: WP_003083775.1
• Coordinates: 5065970..5066197 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBX44_RS23755	5060944..5062293	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
BBX44_RS23760	5062342..5063028	+	687	WP_003083762.1	FadR family transcriptional regulator	-
BBX44_RS23765	5063129..5063862	+	734	Protein_4692	GntR family transcriptional regulator	-
BBX44_RS23770	5064066..5064452	+	387	WP_014602345.1	aegerolysin family protein	-
BBX44_RS23775	5064484..5065392	-	909	WP_023132709.1	LysR family transcriptional regulator	-
BBX44_RS23780	5065692..5065973	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
BBX44_RS23785	5065970..5066197	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
BBX44_RS23790	5066373..5066993	-	621	WP_003101226.1	hypothetical protein	-
BBX44_RS23795	5067094..5067594	+	501	WP_003112629.1	LEA type 2 family protein	-
BBX44_RS23800	5067667..5068008	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
BBX44_RS23805	5068090..5069517	-	1428	WP_003083784.1	GABA permease	-
BBX44_RS23810	5069686..5071179	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T86580 WP_003083773.1 NZ_CP024024:c5065973-5065692 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T86580 NZ_CP024024:c5065973-5065692 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGATAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT86580 WP_003083775.1 NZ_CP024024:c5066197-5065970 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT86580 NZ_CP024024:c5066197-5065970 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9