Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2914339..2914886 Replicon chromosome
Accession NZ_CP024024
Organism Pseudomonas aeruginosa strain PARM801

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BBX44_RS13660 Protein ID WP_121496487.1
Coordinates 2914339..2914614 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BBX44_RS13665 Protein ID WP_121496486.1
Coordinates 2914614..2914886 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBX44_RS13635 2909632..2910678 - 1047 WP_121496492.1 NAD(P)-dependent oxidoreductase -
BBX44_RS13640 2910671..2911345 - 675 WP_124083107.1 hypothetical protein -
BBX44_RS13645 2911357..2911839 - 483 WP_121496490.1 adenylyltransferase/cytidyltransferase family protein -
BBX44_RS13650 2911847..2912350 - 504 WP_121496489.1 GNAT family N-acetyltransferase -
BBX44_RS13655 2912340..2913653 - 1314 WP_162950080.1 aminotransferase class III-fold pyridoxal phosphate-dependent enzyme -
BBX44_RS13660 2914339..2914614 - 276 WP_121496487.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BBX44_RS13665 2914614..2914886 - 273 WP_121496486.1 ribbon-helix-helix domain-containing protein Antitoxin
BBX44_RS13670 2915146..2915706 + 561 WP_023102601.1 recombinase family protein -
BBX44_RS13675 2915763..2916488 - 726 WP_188129804.1 hypothetical protein -
BBX44_RS13680 2916520..2917185 - 666 WP_121496494.1 DUF3218 family protein -
BBX44_RS13685 2917196..2918227 - 1032 WP_121496485.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2851917..2961665 109748


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10688.33 Da        Isoelectric Point: 10.4249

>T86577 WP_121496487.1 NZ_CP024024:c2914614-2914339 [Pseudomonas aeruginosa]
MELKWTNKGLSDLTRLYEFLAAVNRSAAARTVQQLTSAPTKLLANPRIGERLEEFDPRDVRRILVGHYEMRYEIAGSTIY
LLRLWHTRKDR

Download         Length: 276 bp

>T86577 NZ_CP024024:c2914614-2914339 [Pseudomonas aeruginosa]
ATGGAGTTGAAGTGGACGAACAAGGGGCTGTCCGATCTGACTCGACTATATGAGTTCCTGGCGGCTGTGAACCGTTCCGC
TGCGGCACGTACCGTGCAACAGCTAACGAGCGCACCGACTAAGCTGCTGGCCAACCCGCGCATCGGTGAGCGCCTGGAAG
AGTTCGATCCGCGTGACGTGCGCCGGATTCTGGTCGGGCATTACGAGATGCGCTACGAAATTGCGGGCTCTACCATCTAT
CTGCTGCGTCTGTGGCACACCCGTAAAGATCGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10131.35 Da        Isoelectric Point: 4.5127

>AT86577 WP_121496486.1 NZ_CP024024:c2914886-2914614 [Pseudomonas aeruginosa]
MPANAKTRSVTAHVPIELAERVDDIAERLERSKNWIVKQALTAWLDQEDERSRLTREALVDVDDGCVIDHQAVQAWADSL
STDTPLPVPR

Download         Length: 273 bp

>AT86577 NZ_CP024024:c2914886-2914614 [Pseudomonas aeruginosa]
ATGCCCGCTAACGCCAAAACCAGATCTGTCACCGCCCATGTCCCCATTGAGCTGGCCGAACGTGTCGATGACATCGCAGA
GCGCCTGGAGCGCTCCAAGAACTGGATCGTCAAGCAGGCTCTTACAGCCTGGCTCGACCAGGAAGACGAGCGTAGCCGCC
TGACCCGCGAGGCTCTGGTGGATGTGGATGACGGCTGCGTGATTGACCATCAGGCAGTCCAGGCCTGGGCCGATAGCCTT
AGTACCGACACTCCGCTGCCGGTGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References