Detailed information of TA system TA086573

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 330313..331352
• Replicon: chromosome
• Accession: NZ_CP024024
• Organism: Pseudomonas aeruginosa strain PARM801

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: BBX44_RS01635
• Protein ID: WP_084310712.1
• Coordinates: 330313..330888 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: BBX44_RS01640
• Protein ID: WP_084310711.1
• Coordinates: 330885..331352 (-)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBX44_RS01610	325324..325596	-	273	WP_203448165.1	DNA-binding protein	-
BBX44_RS01615	325710..325981	+	272	Protein_318	DNA-binding protein	-
BBX44_RS01620	326548..328404	-	1857	WP_203448167.1	DUF2075 domain-containing protein	-
BBX44_RS01625	328434..328817	-	384	WP_203448169.1	nucleotide pyrophosphohydrolase	-
BBX44_RS01630	329119..330261	+	1143	WP_203448171.1	DUF3883 domain-containing protein	-
BBX44_RS01635	330313..330888	-	576	WP_084310712.1	PIN domain-containing protein	Toxin
BBX44_RS01640	330885..331352	-	468	WP_084310711.1	helix-turn-helix domain-containing protein	Antitoxin
BBX44_RS01645	331774..332127	-	354	WP_203448173.1	hypothetical protein	-
BBX44_RS01650	332250..333803	+	1554	WP_203448175.1	recombinase family protein	-
BBX44_RS01655	333809..334699	+	891	WP_203448329.1	ParB N-terminal domain-containing protein	-
BBX44_RS01660	334696..335601	+	906	WP_203448177.1	ParB N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	307776..339543	31767

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-114)

Antitoxin

• Helix-turn-helix domain, group 17 (84-130)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21717.70 Da
• Isoelectric Point: 4.6564

>T86573 WP_084310712.1 NZ_CP024024:c330888-330313 [Pseudomonas aeruginosa]
MRHTPFTAIYDANVLYPAPLRDFLMHLALTGVYRARWTAQIHDEWKRNLLLNRTDLTQEQVDRTSALMDRAVPDALVTGY
ESLCAGLDLPDVDDRHVLAAAIKCNASVIVTFNLRDFPDSVLAPLEIEALHPDDFIADLWDLDQAAVLEAAQRQRASLRN
PPHTAREYLDKLLQQELTQTERLLSSFELVI

Nucleotide

• Length: 576 bp

>T86573 NZ_CP024024:c330888-330313 [Pseudomonas aeruginosa]
ATGAGGCATACACCCTTTACCGCCATTTATGATGCAAATGTTCTCTACCCTGCCCCTCTTCGTGACTTCCTGATGCATCT
TGCTCTGACTGGCGTGTACCGCGCACGCTGGACCGCGCAGATCCATGATGAATGGAAGCGTAACCTTCTGCTGAATCGAA
CCGACCTTACTCAGGAGCAAGTCGATCGCACCTCGGCACTGATGGATCGTGCTGTGCCCGACGCACTTGTGACGGGCTAT
GAGTCTCTCTGCGCAGGTCTGGACCTTCCCGACGTGGATGATCGCCATGTGCTTGCCGCAGCGATCAAATGTAATGCTTC
AGTTATCGTGACCTTCAACCTGAGAGACTTCCCCGATTCGGTGCTCGCGCCACTCGAAATCGAGGCGTTGCACCCTGATG
ATTTCATCGCTGACCTCTGGGACTTGGATCAGGCGGCAGTCTTAGAGGCTGCGCAGCGCCAACGAGCATCACTGAGGAAC
CCGCCCCATACAGCGCGGGAGTACCTGGATAAACTGCTTCAGCAGGAGCTAACCCAGACCGAGAGGCTGCTATCGAGCTT
CGAATTGGTGATTTGA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17454.05 Da
• Isoelectric Point: 5.6903

>AT86573 WP_084310711.1 NZ_CP024024:c331352-330885 [Pseudomonas aeruginosa]
MTTADLNRTILPDEKEIAAAVESRRQLAAFLSTKLETQRIELVDEQQKRQVVEMPAFALRLLDNILSELALGNAVKVVPI
HAELTTQEAADLLNVSRPHLVKLLDEGVIPHTKTGRHRRVRFADLMAYKELRDRASREAMDELAAQAQELGMGYE

Nucleotide

• Length: 468 bp

>AT86573 NZ_CP024024:c331352-330885 [Pseudomonas aeruginosa]
ATGACCACCGCCGACCTCAATCGCACAATTCTCCCTGACGAGAAGGAGATTGCTGCGGCCGTGGAATCACGTCGCCAGTT
GGCAGCATTTCTCTCAACCAAGCTAGAGACTCAACGCATCGAGCTGGTCGATGAGCAGCAAAAGCGCCAGGTTGTCGAGA
TGCCAGCATTCGCGCTGCGCTTGCTCGACAATATTCTCAGTGAGTTGGCCCTGGGAAATGCCGTCAAGGTGGTGCCCATC
CATGCGGAACTGACGACCCAGGAAGCGGCTGATCTGCTCAATGTCTCGCGGCCGCACTTGGTGAAACTGCTCGATGAGGG
GGTGATTCCTCACACCAAGACTGGCCGTCACCGCCGGGTCAGGTTCGCTGATCTGATGGCCTACAAGGAGCTGCGAGACC
GCGCTAGTCGTGAAGCCATGGATGAGCTTGCCGCTCAGGCCCAGGAGTTAGGGATGGGGTACGAATGA