Detailed information of TA system TA086572

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 631983..632661
• Replicon: chromosome
• Accession: NZ_CP024023
• Organism: Helicobacter pylori isolate 7.13_D3c

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CNX73_RS03170
• Protein ID: WP_080006198.1
• Coordinates: 632338..632661 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D7FDF9
• Locus tag: CNX73_RS03165
• Protein ID: WP_001134161.1
• Coordinates: 631983..632357 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CNX73_RS03140	627484..627881	+	398	Protein_583	hypothetical protein	-
CNX73_RS03155	628787..630994	+	2208	WP_104937566.1	Hop family adhesin BabA	-
CNX73_RS03165	631983..632357	+	375	WP_001134161.1	hypothetical protein	Antitoxin
CNX73_RS03170	632338..632661	+	324	WP_080006198.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
CNX73_RS03175	632706..633230	-	525	WP_001135637.1	acyl-CoA thioesterase	-
CNX73_RS03180	633370..634218	+	849	WP_000504111.1	SDR family oxidoreductase	-
CNX73_RS03185	634211..635191	+	981	WP_000921449.1	iron ABC transporter permease	-
CNX73_RS03190	635191..635958	+	768	WP_000242349.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12475.74 Da
• Isoelectric Point: 9.5268

>T86572 WP_080006198.1 NZ_CP024023:632338-632661 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILRKKEPLDPQFQDHALKGKWKPYRECHIKPDILLVYLVKDDELILLRLG
SHSELFCKSPTQFITLKPTAQPTTPLF

Nucleotide

• Length: 324 bp

>T86572 NZ_CP024023:632338-632661 [Helicobacter pylori]
GTGTTGAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAAGGAAGTCATTCTAAGAAAGAAAGAACCGCTAGATCCACAATTTCAAGATCATGCCCTAAAAGGCAAGTGGAAGCCTT
ATAGAGAATGCCACATTAAGCCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAACTGATTTTGTTAAGGTTAGGC
AGTCATAGCGAGCTGTTTTGTAAATCACCCACACAATTTATAACGCTTAAACCAACCGCTCAACCAACTACCCCCCTTTT
TTAG

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14713.64 Da
• Isoelectric Point: 7.8113

>AT86572 WP_001134161.1 NZ_CP024023:631983-632357 [Helicobacter pylori]
MPNTTNKDYTQYSEKQLFNLIHQLEQKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCLG
RKIPNIQTQQAMRDVYNKETDLIVEDFSSYSDERKKALGVETQS

Nucleotide

• Length: 375 bp

>AT86572 NZ_CP024023:631983-632357 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGATTACACCCAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCAAAA
AATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACTTTA
AGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTGTTTGGGG
CGCAAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGTGTATAACAAAGAAACAGATTTGATTGTTGAGGATTT
TTCTAGTTACAGCGATGAGAGAAAAAAGGCTTTGGGTGTTGAAACTCAATCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2L2I1T1