Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 123042..123630 Replicon plasmid unnamed1
Accession NZ_CP024012
Organism Acinetobacter sp. LoGeW2-3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BS636_RS15915 Protein ID WP_078191612.1
Coordinates 123042..123338 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BS636_RS15920 Protein ID WP_099339760.1
Coordinates 123340..123630 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BS636_RS15880 118574..119326 + 753 WP_099339756.1 acetolactate decarboxylase -
BS636_RS15890 119470..120795 - 1326 WP_099339757.1 ISNCY family transposase -
BS636_RS15910 122439..122864 - 426 WP_099339759.1 GFA family protein -
BS636_RS15915 123042..123338 + 297 WP_078191612.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BS636_RS15920 123340..123630 + 291 WP_099339760.1 putative addiction module antidote protein Antitoxin
BS636_RS15925 123724..124266 - 543 WP_099339761.1 cysteine hydrolase -
BS636_RS15930 124350..125234 - 885 WP_099339762.1 MBL fold metallo-hydrolase -
BS636_RS15935 125368..126345 + 978 WP_099339807.1 helix-turn-helix domain-containing protein -
BS636_RS15945 126800..127117 - 318 WP_099339763.1 hypothetical protein -
BS636_RS15950 127172..127486 - 315 WP_099339764.1 helix-turn-helix domain-containing protein -
BS636_RS15955 127467..127790 - 324 WP_099339765.1 transcriptional regulator -
BS636_RS15960 128055..128363 + 309 WP_099339766.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..179399 179399


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-83)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11584.29 Da        Isoelectric Point: 7.0155

>T86569 WP_078191612.1 NZ_CP024012:123042-123338 [Acinetobacter sp. LoGeW2-3]
MIEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGSGWRMYYIQHGDVVIVMLGGGDKS
TQQDDIKRAVKLSKTLED

Download         Length: 297 bp

>T86569 NZ_CP024012:123042-123338 [Acinetobacter sp. LoGeW2-3]
ATGATTGAAATTAAACGTCTACCTGAGTTTGATGAATGGTTAGATGGCATTAAAGACAATATGACCCGAATTCGCTTGAA
TCGTAGATTAGATAAGGTTCAACGTGGTAATTGGGGAGATATTAAGCCCTTACAAGATGGGGTTTGGGAAATGAGGGAGT
TCTTTGGATCAGGCTGGCGGATGTATTACATCCAGCATGGTGATGTTGTTATTGTGATGCTTGGTGGAGGAGATAAATCT
ACACAGCAAGACGATATCAAGCGAGCAGTCAAATTATCGAAAACATTGGAGGATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10540.19 Da        Isoelectric Point: 5.1133

>AT86569 WP_099339760.1 NZ_CP024012:123340-123630 [Acinetobacter sp. LoGeW2-3]
MVKVSDLPSFDMAESLKTEEDIVMYLNMVLEENDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRQDSAPRFDTI
NRVVNALGLKLTVQHA

Download         Length: 291 bp

>AT86569 NZ_CP024012:123340-123630 [Acinetobacter sp. LoGeW2-3]
ATGGTTAAAGTTTCTGATTTACCAAGTTTTGATATGGCTGAGTCACTCAAAACTGAAGAAGACATTGTGATGTATCTCAA
TATGGTTCTTGAAGAGAATGATCCAGCTGAATTAGCTCATGCGCTTGGTGTAATTGCAAAAGCTCGTGGCATGACTCAAA
TTGCGAAAGAAGCAGGAATTGGGCGTGAGGCACTGTACAAAGCCCTACGTCAGGATTCAGCACCACGTTTTGACACGATT
AATCGTGTAGTGAATGCTTTAGGCCTAAAACTCACAGTACAGCACGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References