Detailed information of TA system TA086569

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 123042..123630
• Replicon: plasmid unnamed1
• Accession: NZ_CP024012
• Organism: Acinetobacter sp. LoGeW2-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BS636_RS15915
• Protein ID: WP_078191612.1
• Coordinates: 123042..123338 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BS636_RS15920
• Protein ID: WP_099339760.1
• Coordinates: 123340..123630 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BS636_RS15880	118574..119326	+	753	WP_099339756.1	acetolactate decarboxylase	-
BS636_RS15890	119470..120795	-	1326	WP_099339757.1	ISNCY family transposase	-
BS636_RS15910	122439..122864	-	426	WP_099339759.1	GFA family protein	-
BS636_RS15915	123042..123338	+	297	WP_078191612.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BS636_RS15920	123340..123630	+	291	WP_099339760.1	putative addiction module antidote protein	Antitoxin
BS636_RS15925	123724..124266	-	543	WP_099339761.1	cysteine hydrolase	-
BS636_RS15930	124350..125234	-	885	WP_099339762.1	MBL fold metallo-hydrolase	-
BS636_RS15935	125368..126345	+	978	WP_099339807.1	helix-turn-helix domain-containing protein	-
BS636_RS15945	126800..127117	-	318	WP_099339763.1	hypothetical protein	-
BS636_RS15950	127172..127486	-	315	WP_099339764.1	helix-turn-helix domain-containing protein	-
BS636_RS15955	127467..127790	-	324	WP_099339765.1	transcriptional regulator	-
BS636_RS15960	128055..128363	+	309	WP_099339766.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..179399	179399

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-83)

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-92)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11584.29 Da
• Isoelectric Point: 7.0155

>T86569 WP_078191612.1 NZ_CP024012:123042-123338 [Acinetobacter sp. LoGeW2-3]
MIEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGSGWRMYYIQHGDVVIVMLGGGDKS
TQQDDIKRAVKLSKTLED

Nucleotide

• Length: 297 bp

>T86569 NZ_CP024012:123042-123338 [Acinetobacter sp. LoGeW2-3]
ATGATTGAAATTAAACGTCTACCTGAGTTTGATGAATGGTTAGATGGCATTAAAGACAATATGACCCGAATTCGCTTGAA
TCGTAGATTAGATAAGGTTCAACGTGGTAATTGGGGAGATATTAAGCCCTTACAAGATGGGGTTTGGGAAATGAGGGAGT
TCTTTGGATCAGGCTGGCGGATGTATTACATCCAGCATGGTGATGTTGTTATTGTGATGCTTGGTGGAGGAGATAAATCT
ACACAGCAAGACGATATCAAGCGAGCAGTCAAATTATCGAAAACATTGGAGGATTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10540.19 Da
• Isoelectric Point: 5.1133

>AT86569 WP_099339760.1 NZ_CP024012:123340-123630 [Acinetobacter sp. LoGeW2-3]
MVKVSDLPSFDMAESLKTEEDIVMYLNMVLEENDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRQDSAPRFDTI
NRVVNALGLKLTVQHA

Nucleotide

• Length: 291 bp

>AT86569 NZ_CP024012:123340-123630 [Acinetobacter sp. LoGeW2-3]
ATGGTTAAAGTTTCTGATTTACCAAGTTTTGATATGGCTGAGTCACTCAAAACTGAAGAAGACATTGTGATGTATCTCAA
TATGGTTCTTGAAGAGAATGATCCAGCTGAATTAGCTCATGCGCTTGGTGTAATTGCAAAAGCTCGTGGCATGACTCAAA
TTGCGAAAGAAGCAGGAATTGGGCGTGAGGCACTGTACAAAGCCCTACGTCAGGATTCAGCACCACGTTTTGACACGATT
AATCGTGTAGTGAATGCTTTAGGCCTAAAACTCACAGTACAGCACGCCTAA