Detailed information of TA system TA086568

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2804291..2804924
• Replicon: chromosome
• Accession: NZ_CP024011
• Organism: Acinetobacter sp. LoGeW2-3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2D1ISJ1
• Locus tag: BS636_RS13590
• Protein ID: WP_026441143.1
• Coordinates: 2804742..2804924 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: BS636_RS13585
• Protein ID: WP_099339262.1
• Coordinates: 2804291..2804695 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BS636_RS13555	2799446..2799649	-	204	WP_099339256.1	hypothetical protein	-
BS636_RS13560	2799649..2801133	-	1485	WP_099339257.1	DUF935 family protein	-
BS636_RS13565	2801144..2802679	-	1536	WP_099339258.1	phage terminase large subunit	-
BS636_RS13570	2802680..2803150	-	471	WP_099339259.1	DUF2280 domain-containing protein	-
BS636_RS13575	2803196..2803837	-	642	WP_099339260.1	hypothetical protein	-
BS636_RS13580	2803797..2804237	-	441	WP_099339261.1	hypothetical protein	-
BS636_RS13585	2804291..2804695	-	405	WP_099339262.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BS636_RS13590	2804742..2804924	-	183	WP_026441143.1	type II toxin-antitoxin system HicA family toxin	Toxin
BS636_RS16345	2805017..2805190	-	174	WP_171266028.1	hypothetical protein	-
BS636_RS16350	2805203..2805370	-	168	WP_171266029.1	hypothetical protein	-
BS636_RS13595	2806023..2806463	-	441	WP_099339263.1	hypothetical protein	-
BS636_RS13600	2806476..2806718	-	243	WP_005026858.1	hypothetical protein	-
BS636_RS13605	2806718..2807137	-	420	WP_099339264.1	hypothetical protein	-
BS636_RS13610	2807130..2807519	-	390	WP_099339265.1	hypothetical protein	-
BS636_RS13615	2807516..2807752	-	237	WP_099339266.1	hypothetical protein	-
BS636_RS13620	2807749..2808015	-	267	WP_099339267.1	hypothetical protein	-
BS636_RS16355	2808012..2808170	-	159	WP_171266030.1	hypothetical protein	-
BS636_RS13625	2808167..2808427	-	261	WP_099339268.1	hypothetical protein	-
BS636_RS13630	2808424..2809182	-	759	WP_099339269.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2774464..2831357	56893

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6783.04 Da
• Isoelectric Point: 10.4906

>T86568 WP_026441143.1 NZ_CP024011:c2804924-2804742 [Acinetobacter sp. LoGeW2-3]
MKSLDLIKMIEADGWYQVRCKGDHHHFKHPTKKGLVTIPHPKKDLPPGTVNSILKQAGLK

Nucleotide

• Length: 183 bp

>T86568 NZ_CP024011:c2804924-2804742 [Acinetobacter sp. LoGeW2-3]
ATGAAAAGTCTGGATTTAATCAAGATGATTGAAGCAGACGGTTGGTATCAAGTTAGATGTAAGGGTGATCATCATCATTT
CAAACATCCTACTAAGAAGGGGTTGGTTACGATTCCTCATCCTAAAAAGGATTTACCACCTGGCACTGTGAATAGCATTC
TGAAGCAAGCGGGTCTCAAGTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14756.67 Da
• Isoelectric Point: 4.3461

>AT86568 WP_099339262.1 NZ_CP024011:c2804695-2804291 [Acinetobacter sp. LoGeW2-3]
MLYPIAVERGSDKEAYGVIVPDIPGCFSAGDTFEEALENVKEAIAGHLEILAEDGEDIPLASEAANFFDNEDYQGMVWAV
VDIDVSRYLGKAEKVNVTLPSRLIHLIDDRVKKDARFKSRSAFLAASAERMLHA

Nucleotide

• Length: 405 bp

>AT86568 NZ_CP024011:c2804695-2804291 [Acinetobacter sp. LoGeW2-3]
ATGTTATATCCAATCGCAGTAGAGAGAGGCTCAGACAAAGAAGCCTACGGTGTGATTGTCCCTGATATTCCAGGTTGTTT
TTCAGCAGGTGATACTTTTGAAGAGGCACTTGAGAATGTGAAAGAGGCAATCGCTGGACATTTAGAGATTTTAGCTGAAG
ATGGTGAGGATATTCCTTTGGCATCCGAAGCTGCTAATTTCTTTGATAATGAAGATTATCAAGGTATGGTTTGGGCAGTG
GTCGATATTGATGTAAGTCGTTATCTGGGTAAGGCGGAAAAAGTAAACGTCACTTTACCAAGCCGCTTAATTCATTTAAT
TGACGATCGTGTGAAGAAAGATGCACGTTTTAAATCACGCTCAGCATTTTTGGCTGCGAGTGCAGAAAGAATGCTTCATG
CTTAA

Structures

Toxin

• AlphaFold DB: A0A2D1ISJ1