Detailed information of TA system TA086565

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1330074..1330714
• Replicon: chromosome
• Accession: NZ_CP023994
• Organism: Aurantimicrobium sp. MWH-Mo1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AURMO_RS06625
• Protein ID: WP_162532695.1
• Coordinates: 1330074..1330472 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: AURMO_RS06630
• Protein ID: WP_110234907.1
• Coordinates: 1330472..1330714 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AURMO_RS06600	1325191..1325772	-	582	WP_110234246.1	aminoacyl-tRNA hydrolase	-
AURMO_RS06605	1325781..1326497	-	717	WP_110234248.1	50S ribosomal protein L25/general stress protein Ctc	-
AURMO_RS06610	1326787..1328235	+	1449	WP_110234250.1	NADP-dependent phosphogluconate dehydrogenase	-
AURMO_RS06615	1328278..1329222	+	945	WP_110234252.1	carbohydrate kinase	-
AURMO_RS06620	1329228..1330073	+	846	WP_110234254.1	hypothetical protein	-
AURMO_RS06625	1330074..1330472	-	399	WP_162532695.1	type II toxin-antitoxin system VapC family toxin	Toxin
AURMO_RS06630	1330472..1330714	-	243	WP_110234907.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AURMO_RS06635	1330863..1331840	-	978	WP_110234258.1	ribose-phosphate diphosphokinase	-
AURMO_RS06640	1331880..1333301	-	1422	WP_110234260.1	bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU	-
AURMO_RS06650	1333465..1333977	+	513	WP_110234262.1	MarR family transcriptional regulator	-
AURMO_RS06655	1333981..1334346	+	366	WP_110234264.1	hypothetical protein	-
AURMO_RS06660	1334445..1334702	+	258	WP_162532696.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
AURMO_RS06665	1334699..1335073	+	375	WP_110234268.1	type II toxin-antitoxin system VapC family toxin	-
AURMO_RS06670	1335074..1335469	-	396	WP_110234270.1	hypothetical protein	-
AURMO_RS06675	1335466..1335675	-	210	WP_110234272.1	type II toxin-antitoxin system HicA family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• SpoVT-AbrB domain (12-49)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14725.99 Da
• Isoelectric Point: 6.2308

>T86565 WP_162532695.1 NZ_CP023994:c1330472-1330074 [Aurantimicrobium sp. MWH-Mo1]
VGYLFDTNILIHLDRHGDLELAERVQSVMSDSGVSSIAVMEMYYGVARSTHIEPNLIKTKSLLSIFPIFEFTAADAFETG
MLRAELRRAGTPIGPFEVCIAGQARARKLTLITANVREFERVPGLRVENWLS

Nucleotide

• Length: 399 bp

>T86565 NZ_CP023994:c1330472-1330074 [Aurantimicrobium sp. MWH-Mo1]
GTGGGTTACCTCTTTGATACGAACATCCTTATTCATCTTGACCGTCACGGTGATCTTGAACTTGCTGAGCGTGTTCAATC
TGTGATGTCAGATTCGGGTGTTTCTTCCATCGCAGTGATGGAGATGTATTACGGAGTGGCCCGATCAACTCACATTGAAC
CAAATTTGATCAAGACGAAATCTTTGTTGAGCATTTTCCCTATCTTCGAATTTACTGCAGCAGACGCGTTTGAAACTGGA
ATGCTTCGCGCCGAATTACGACGTGCAGGGACGCCTATTGGCCCATTTGAGGTGTGCATAGCAGGCCAAGCTCGAGCCCG
AAAACTCACTCTAATTACTGCAAATGTTCGTGAATTTGAACGCGTTCCCGGACTTCGCGTAGAGAACTGGTTGAGCTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9076.25 Da
• Isoelectric Point: 4.1074

>AT86565 WP_110234907.1 NZ_CP023994:c1330714-1330472 [Aurantimicrobium sp. MWH-Mo1]
MTSSKIFYNNTTQAVRLPKDVAFPLEVTEVDIFIQGETRVIAPKGQSLVAWMQTGPHFTSDFMVDRDQPPMPEDEEGIFE

Nucleotide

• Length: 243 bp

>AT86565 NZ_CP023994:c1330714-1330472 [Aurantimicrobium sp. MWH-Mo1]
ATGACTTCAAGCAAAATCTTCTACAACAACACAACCCAAGCGGTGCGGTTACCCAAGGACGTCGCGTTTCCTTTAGAAGT
AACCGAGGTAGACATTTTCATTCAGGGTGAAACCCGAGTTATTGCCCCTAAGGGGCAAAGTCTCGTTGCCTGGATGCAAA
CCGGTCCACATTTCACTTCGGACTTCATGGTTGACAGGGATCAGCCCCCCATGCCTGAAGACGAAGAAGGGATATTCGAA
TAG