Detailed information of TA system TA086563

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 3890658..3891229
• Replicon: chromosome
• Accession: NZ_CP023992
• Organism: Streptomyces malaysiensis strain DSM 4137

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: SMALA_RS15165
• Protein ID: WP_079257839.1
• Coordinates: 3890658..3891032 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1P8XVF0
• Locus tag: SMALA_RS15170
• Protein ID: WP_069863663.1
• Coordinates: 3891032..3891229 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMALA_RS15150	3886279..3887064	-	786	WP_069863678.1	hypothetical protein	-
SMALA_RS15155	3887207..3887848	-	642	WP_069863676.1	helix-turn-helix domain-containing protein	-
SMALA_RS15160	3888750..3890546	-	1797	WP_079152962.1	DEAD/DEAH box helicase	-
SMALA_RS15165	3890658..3891032	-	375	WP_079257839.1	Fic family protein	Toxin
SMALA_RS15170	3891032..3891229	-	198	WP_069863663.1	Arc family DNA-binding protein	Antitoxin
SMALA_RS15175	3891263..3892756	-	1494	WP_099013914.1	MFS transporter	-
SMALA_RS15180	3893064..3894179	-	1116	WP_167460021.1	putative sulfate exporter family transporter	-
SMALA_RS15185	3894182..3894751	-	570	WP_079257842.1	cysteine dioxygenase family protein	-
SMALA_RS15190	3894922..3895827	-	906	WP_069863657.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (11-80)

Antitoxin

• Arc-like DNA binding domain (4-42)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14001.81 Da
• Isoelectric Point: 4.7465

>T86563 WP_079257839.1 NZ_CP023992:c3891032-3890658 [Streptomyces malaysiensis]
MHYLTLPELLNLAERLGESEVRDYGLLESALARPQASVFGQDAYPDVWQKAAALMESSARNHALVDGNKRLSWYATWVFL
HINGHPLHADFDVDEAERFVLSVCQGELDVAKIAEGLTRFTERM

Nucleotide

• Length: 375 bp

>T86563 NZ_CP023992:c3891032-3890658 [Streptomyces malaysiensis]
ATGCACTACCTCACGCTGCCCGAGCTGCTGAACCTCGCCGAGCGTCTCGGGGAGAGCGAAGTGCGCGACTACGGGCTGCT
GGAGTCCGCGCTGGCCCGTCCGCAGGCGAGTGTGTTCGGGCAGGACGCCTACCCGGACGTGTGGCAGAAGGCCGCTGCGC
TGATGGAGTCGTCGGCTCGCAACCACGCCTTGGTGGACGGCAACAAGCGGCTCTCCTGGTATGCGACCTGGGTCTTCCTC
CACATCAATGGGCATCCGCTGCACGCGGACTTCGACGTCGACGAGGCCGAGCGCTTCGTGCTGAGCGTCTGCCAGGGCGA
GCTGGACGTGGCGAAGATCGCGGAGGGGCTGACCCGGTTCACGGAAAGAATGTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7439.31 Da
• Isoelectric Point: 5.6033

>AT86563 WP_069863663.1 NZ_CP023992:c3891229-3891032 [Streptomyces malaysiensis]
MAALNLRFTDEELDALRKRAEAEGRSMQSFAHDAVMAAINEHSRRFDEAADHVLRVSEELNRRLA

Nucleotide

• Length: 198 bp

>AT86563 NZ_CP023992:c3891229-3891032 [Streptomyces malaysiensis]
ATGGCCGCGCTGAATCTACGTTTTACGGACGAAGAGCTCGACGCCTTGCGCAAGCGCGCGGAGGCGGAGGGCCGGAGCAT
GCAGTCGTTCGCCCACGACGCGGTGATGGCGGCGATCAATGAGCACTCCCGGCGGTTCGACGAGGCCGCCGACCATGTGT
TGCGGGTGAGCGAAGAGCTCAACCGGAGGCTCGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1P8XVF0