Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2447750..2448285 Replicon chromosome
Accession NZ_CP023970
Organism Staphylococcus lugdunensis strain FDAARGOS_381

Toxin (Protein)


Gene name TscT Uniprot ID C5QLS6
Locus tag CRN64_RS11660 Protein ID WP_002445368.1
Coordinates 2447962..2448285 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID C5QLS5
Locus tag CRN64_RS11655 Protein ID WP_001058489.1
Coordinates 2447750..2447959 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN64_RS11620 2443006..2443290 + 285 WP_002461410.1 co-chaperone GroES -
CRN64_RS11625 2443350..2444972 + 1623 WP_002461409.1 chaperonin GroEL -
CRN64_RS11630 2445041..2446213 - 1173 WP_002492309.1 site-specific integrase -
CRN64_RS11635 2446227..2446901 - 675 WP_002445345.1 helix-turn-helix transcriptional regulator -
CRN64_RS11640 2447074..2447292 + 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
CRN64_RS11645 2447297..2447614 + 318 WP_002445364.1 helix-turn-helix domain-containing protein -
CRN64_RS11650 2447611..2447757 + 147 WP_002445365.1 hypothetical protein -
CRN64_RS11655 2447750..2447959 + 210 WP_001058489.1 hypothetical protein Antitoxin
CRN64_RS11660 2447962..2448285 + 324 WP_002445368.1 DUF1474 family protein Toxin
CRN64_RS11665 2448349..2449218 + 870 WP_002445370.1 primase alpha helix C-terminal domain-containing protein -
CRN64_RS11670 2449232..2450941 + 1710 WP_098903159.1 DUF927 domain-containing protein -
CRN64_RS11675 2451289..2451654 + 366 WP_002445372.1 hypothetical protein -
CRN64_RS11680 2451668..2452309 + 642 WP_002492310.1 pathogenicity island protein -
CRN64_RS11685 2452597..2452941 + 345 WP_002445374.1 hypothetical protein -
CRN64_RS11690 2452955..2453188 + 234 WP_002492317.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 2443006..2458423 15417


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 13107.51 Da        Isoelectric Point: 4.8571

>T86552 WP_002445368.1 NZ_CP023970:2447962-2448285 [Staphylococcus lugdunensis]
MNWEIKNLFSDLKLLKDSFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDKIIQ
KFHELEKASSENFGEESDDAQKLKITE

Download         Length: 324 bp

>T86552 NZ_CP023970:2447962-2448285 [Staphylococcus lugdunensis]
ATGAATTGGGAAATTAAAAATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAATCATGG
TTGGCATTTTGAGGAGTTATATCCACATGAACCAAATCATAACTTAAATAAAGATGAATTAATTAGAGAGGGTTTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAACAGTTCGATAAAATTATACAA
AAGTTTCATGAATTAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCACAAAAATTAAAAATCACAGA
GTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8225.24 Da        Isoelectric Point: 4.2820

>AT86552 WP_001058489.1 NZ_CP023970:2447750-2447959 [Staphylococcus lugdunensis]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT86552 NZ_CP023970:2447750-2447959 [Staphylococcus lugdunensis]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A853V601

References