Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2396101..2396618 Replicon chromosome
Accession NZ_CP023970
Organism Staphylococcus lugdunensis strain FDAARGOS_381

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag CRN64_RS11400 Protein ID WP_002461192.1
Coordinates 2396268..2396618 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag CRN64_RS11395 Protein ID WP_002461193.1
Coordinates 2396101..2396271 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN64_RS11370 2391926..2392408 + 483 WP_002492078.1 PH domain-containing protein -
CRN64_RS11375 2392401..2393915 + 1515 WP_002492082.1 PH domain-containing protein -
CRN64_RS11380 2393902..2394414 + 513 WP_002461197.1 PH domain-containing protein -
CRN64_RS11385 2394426..2394818 + 393 WP_002461196.1 holo-ACP synthase -
CRN64_RS11390 2394866..2396014 + 1149 WP_002492086.1 alanine racemase -
CRN64_RS11395 2396101..2396271 + 171 WP_002461193.1 hypothetical protein Antitoxin
CRN64_RS11400 2396268..2396618 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CRN64_RS11405 2397052..2398053 + 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
CRN64_RS11410 2398144..2398470 + 327 WP_002461190.1 anti-sigma factor antagonist -
CRN64_RS11415 2398472..2398951 + 480 WP_098903157.1 anti-sigma B factor RsbW -
CRN64_RS11420 2398926..2399696 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T86551 WP_002461192.1 NZ_CP023970:2396268-2396618 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T86551 NZ_CP023970:2396268-2396618 [Staphylococcus lugdunensis]
ATGATTAGACGCGGCGATGTATATTTAGCTGATTTATCACCGGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGT
TATCATTCAAAATGACACCGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCAATTACTGGAAGGATTAATAAAGCGA
AAATACCCACTCATGTGGAAATAGGTAAAAAGAAATATAAGTTAGATAAAGATTCTGTTATTCTGTTAGAGCAAATACGA
ACATTAGATAAAAAAAGATTAAAAGAAAAACTTACTTATCTCTCTGAGGATAAAATGAAAGAAGTAGATCATGCCCTAGA
CATTAGTCTAGGTTTACATAACTATCATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT86551 WP_002461193.1 NZ_CP023970:2396101-2396271 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT86551 NZ_CP023970:2396101-2396271 [Staphylococcus lugdunensis]
ATGCTAACTTTTAATCAAAATCGTAGTCATAGTCTAGAACAGTCATTAAAAGAAGGGTATGCTCAGATGGCAGACCTTAA
TCTCTCCCTAGCAACAGAGGCTTTTCCAATTGAATGTGAAGCTTGTGATTGCAATGAAACTTATCTAACTTCCAATCATC
AGAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References