86550

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2384704..2385222 Replicon chromosome
Accession NZ_CP023970
Organism Staphylococcus lugdunensis strain FDAARGOS_381

Toxin (Protein)


Gene name TsdT Uniprot ID A0A853V532
Locus tag CRN64_RS11340 Protein ID WP_002492077.1
Coordinates 2385010..2385222 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A853V130
Locus tag CRN64_RS11335 Protein ID WP_002492098.1
Coordinates 2384704..2384997 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN64_RS11315 2380304..2380942 + 639 WP_002492090.1 thiamine phosphate synthase -
CRN64_RS11320 2381032..2381907 + 876 WP_002461212.1 membrane protein insertase YidC -
CRN64_RS11325 2382291..2382932 - 642 WP_002492092.1 HD domain-containing protein -
CRN64_RS11330 2383054..2384538 - 1485 WP_002478972.1 cardiolipin synthase -
CRN64_RS11335 2384704..2384997 + 294 WP_002492098.1 copper-sensing transcriptional repressor CsoR Antitoxin
CRN64_RS11340 2385010..2385222 + 213 WP_002492077.1 heavy-metal-associated domain-containing protein Toxin
CRN64_RS11345 2385313..2385450 + 138 WP_002461206.1 hypothetical protein -
CRN64_RS11350 2385864..2387053 - 1190 Protein_2190 rod shape-determining protein RodA -
CRN64_RS11355 2387409..2388479 + 1071 WP_002461204.1 D-alanine--D-alanine ligase -
CRN64_RS11360 2388497..2389855 + 1359 WP_002492089.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-90)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8087.02 Da        Isoelectric Point: 3.9947

>T86550 WP_002492077.1 NZ_CP023970:2385010-2385222 [Staphylococcus lugdunensis]
VEKRLIYITNVTNEDDLENLRTRLLEMIGVNEVVINFDERAVNVTFETSTNLNALEKEIYDAGYHAIDDL

Download         Length: 213 bp

>T86550 NZ_CP023970:2385010-2385222 [Staphylococcus lugdunensis]
GTGGAAAAGCGATTAATTTATATTACAAATGTGACTAATGAAGACGACTTGGAAAACTTACGAACAAGGTTATTAGAGAT
GATTGGTGTTAATGAAGTAGTGATCAATTTTGATGAACGTGCAGTTAATGTTACTTTCGAAACATCAACTAATTTAAATG
CACTTGAAAAAGAAATATATGATGCTGGCTATCATGCTATAGATGATTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11177.85 Da        Isoelectric Point: 6.6367

>AT86550 WP_002492098.1 NZ_CP023970:2384704-2384997 [Staphylococcus lugdunensis]
MNEQDHAHHSKIVKANLKSRLNRIEGQVRAINRMVEDDVYCDDVLTQIRATRSALTSVATKLLEHHMKSCIMDKINDGQE
VEAMEELLVTFQKMLKD

Download         Length: 294 bp

>AT86550 NZ_CP023970:2384704-2384997 [Staphylococcus lugdunensis]
TTGAACGAACAAGATCATGCACATCATTCTAAAATTGTAAAAGCAAATTTAAAATCTAGATTAAATCGTATAGAAGGACA
AGTGCGGGCAATTAATCGCATGGTTGAAGATGATGTTTATTGTGATGATGTGTTAACACAAATAAGAGCAACACGCTCAG
CATTAACGAGTGTAGCAACAAAACTATTAGAGCATCATATGAAAAGTTGTATCATGGATAAAATAAACGATGGGCAGGAA
GTTGAAGCGATGGAGGAATTGCTAGTTACATTTCAAAAGATGCTAAAAGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V532

Antitoxin

Source ID Structure
AlphaFold DB A0A853V130

References