Detailed information of TA system TA086549

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 6369297..6369819
• Replicon: chromosome
• Accession: NZ_CP023969
• Organism: Pseudomonas sp. FDAARGOS_380

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A921NN65
• Locus tag: CRN80_RS29645
• Protein ID: WP_032892910.1
• Coordinates: 6369526..6369819 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7Y1LCT8
• Locus tag: CRN80_RS29640
• Protein ID: WP_020301039.1
• Coordinates: 6369297..6369536 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRN80_RS29610	6365193..6366134	+	942	WP_044272854.1	LysR family transcriptional regulator	-
CRN80_RS29615	6366241..6366555	+	315	WP_098952451.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CRN80_RS29620	6366558..6366845	+	288	WP_056791674.1	helix-turn-helix domain-containing protein	-
CRN80_RS29625	6367090..6368316	+	1227	WP_056791672.1	MFS transporter	-
CRN80_RS29630	6368389..6368643	-	255	WP_098952452.1	DUF3077 domain-containing protein	-
CRN80_RS29640	6369297..6369536	+	240	WP_020301039.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CRN80_RS29645	6369526..6369819	+	294	WP_032892910.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CRN80_RS29655	6370088..6370801	-	714	WP_027604309.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
CRN80_RS29660	6370829..6371587	-	759	WP_003189469.1	MBL fold metallo-hydrolase	-
CRN80_RS29665	6371592..6372707	-	1116	WP_098952456.1	outer membrane protein assembly factor BamC	-
CRN80_RS29670	6372725..6373603	-	879	WP_014717368.1	4-hydroxy-tetrahydrodipicolinate synthase	-
CRN80_RS29675	6373866..6374426	+	561	WP_003189463.1	glycine cleavage system protein R	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-81)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11597.37 Da
• Isoelectric Point: 10.0977

>T86549 WP_032892910.1 NZ_CP023969:6369526-6369819 [Pseudomonas sp. FDAARGOS_380]
MTYSLDFDARALKEWQKLGDTLRQQLKKKLVEILNNPRIEANRLHSLPDCYKIKLRSSGYRLVYQVIDQEITVFVVAVDK
RERDQAYRKASERLEQR

Nucleotide

• Length: 294 bp

>T86549 NZ_CP023969:6369526-6369819 [Pseudomonas sp. FDAARGOS_380]
ATGACCTATAGCCTTGATTTTGATGCGCGTGCATTGAAGGAATGGCAAAAGCTCGGTGACACCCTCCGTCAGCAACTCAA
AAAGAAGCTGGTCGAAATCCTGAACAACCCACGTATTGAAGCTAATCGCCTACATAGCCTGCCTGACTGCTACAAGATCA
AACTGCGTAGCAGCGGGTACAGGCTGGTGTATCAAGTGATCGATCAAGAAATTACAGTGTTCGTGGTCGCCGTTGATAAA
CGTGAGCGTGATCAGGCTTATCGCAAAGCGTCTGAGCGCCTTGAACAGCGCTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9027.43 Da
• Isoelectric Point: 4.6017

>AT86549 WP_020301039.1 NZ_CP023969:6369297-6369536 [Pseudomonas sp. FDAARGOS_380]
MASINIRIDDDLKTRAYLELEKLGVTPSELIRQALQYVAERGQLPFKPVLMTEEDEALMATVRERLASPQRVRVSLDDL

Nucleotide

• Length: 240 bp

>AT86549 NZ_CP023969:6369297-6369536 [Pseudomonas sp. FDAARGOS_380]
TTGGCATCTATCAACATCCGTATCGATGACGACCTGAAAACTCGCGCCTACTTGGAGCTGGAGAAACTCGGTGTCACCCC
TTCCGAACTGATACGCCAGGCGTTGCAATATGTTGCCGAGCGCGGCCAGTTGCCATTTAAGCCTGTGCTGATGACTGAAG
AGGATGAAGCCTTGATGGCGACGGTACGTGAGCGCCTTGCGTCGCCTCAACGAGTGAGGGTTTCTTTGGATGACCTATAG

Structures

Antitoxin

• AlphaFold DB: A0A7Y1LCT8