Detailed information of TA system TA086547

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 4625771..4626384
• Replicon: chromosome
• Accession: NZ_CP023969
• Organism: Pseudomonas sp. FDAARGOS_380

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CRN80_RS21895
• Protein ID: WP_098951099.1
• Coordinates: 4626133..4626384 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A854B833
• Locus tag: CRN80_RS21890
• Protein ID: WP_014718824.1
• Coordinates: 4625771..4626136 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRN80_RS21870	4621020..4622048	-	1029	WP_098951092.1	ABC transporter ATP-binding protein	-
CRN80_RS21875	4622290..4623120	+	831	WP_098951094.1	IclR family transcriptional regulator	-
CRN80_RS21880	4623201..4624556	+	1356	WP_098951096.1	MATE family efflux transporter	-
CRN80_RS21885	4624598..4625770	+	1173	WP_098951097.1	MFS transporter	-
CRN80_RS21890	4625771..4626136	-	366	WP_014718824.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CRN80_RS21895	4626133..4626384	-	252	WP_098951099.1	type II toxin-antitoxin system HicA family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9508.07 Da
• Isoelectric Point: 10.0459

>T86547 WP_098951099.1 NZ_CP023969:c4626384-4626133 [Pseudomonas sp. FDAARGOS_380]
VSKNEKLLAKPLNEHMAFTWSELVTLLRRLGYTQIEGAGSRVKFDIGDPSAMITLHKPHLGNELKHYIRRQIIEQLKSGE
LIQ

Nucleotide

• Length: 252 bp

>T86547 NZ_CP023969:c4626384-4626133 [Pseudomonas sp. FDAARGOS_380]
GTGTCCAAAAATGAAAAGCTGCTCGCCAAACCGCTCAATGAGCACATGGCATTTACCTGGTCTGAGCTCGTCACGTTATT
ACGCCGATTGGGATACACACAGATTGAAGGGGCCGGAAGCCGGGTCAAGTTCGACATTGGCGACCCCAGTGCAATGATCA
CCCTGCACAAGCCTCACCTCGGCAACGAACTGAAACACTACATTCGGCGCCAGATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13248.12 Da
• Isoelectric Point: 7.3725

>AT86547 WP_014718824.1 NZ_CP023969:c4626136-4625771 [Pseudomonas sp. FDAARGOS_380]
VNNQLKHKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFRGAVDDYLATCQSLGHTPEKPCKGSFNVRVGH
DLHLAAALAANRKKVTLNDLTRQALNEFLQHHYPEPCPTIG

Nucleotide

• Length: 366 bp

>AT86547 NZ_CP023969:c4626136-4625771 [Pseudomonas sp. FDAARGOS_380]
GTGAACAACCAACTGAAACACAAAGGCTACATCGGCTCCATCGAAGCCAGCCTCGAGGACAACTGCCTGTTTGGTAAAAT
CCTGTTCATCAAGGCATTGGTGAGCTATGAAGGCAAAACTGTGGCTGAACTGGACGCAGCCTTCCGTGGCGCGGTGGATG
ATTATCTCGCTACCTGCCAGAGCCTGGGGCACACGCCGGAGAAACCGTGCAAAGGTTCATTCAACGTACGCGTCGGGCAT
GACTTGCATTTGGCCGCTGCCCTGGCGGCAAACCGTAAGAAAGTGACATTGAATGATCTCACGCGTCAGGCGCTGAACGA
GTTTCTGCAGCATCATTACCCAGAGCCATGCCCAACGATTGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A854B833