Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 836653..837459 Replicon chromosome
Accession NZ_CP023966
Organism Staphylococcus capitis strain FDAARGOS_378

Toxin (Protein)


Gene name tsbT Uniprot ID A0A507SPY8
Locus tag CRN29_RS04155 Protein ID WP_023350045.1
Coordinates 837280..837459 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A1J4ECT8
Locus tag CRN29_RS04150 Protein ID WP_002453580.1
Coordinates 836653..837252 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN29_RS04130 832541..833998 + 1458 WP_023350042.1 ABC transporter substrate-binding protein/permease -
CRN29_RS04135 833991..834713 + 723 WP_030063521.1 amino acid ABC transporter ATP-binding protein -
CRN29_RS04140 834837..836000 + 1164 WP_087671673.1 tRNA epoxyqueuosine(34) reductase QueG -
CRN29_RS04145 836003..836473 + 471 WP_023350044.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
CRN29_RS04150 836653..837252 + 600 WP_002453580.1 glucosamine-6-phosphate isomerase Antitoxin
CRN29_RS04155 837280..837459 + 180 WP_023350045.1 hypothetical protein Toxin
CRN29_RS04160 837646..838044 + 399 WP_023350046.1 hypothetical protein -
CRN29_RS04165 838198..839583 + 1386 WP_023350047.1 class II fumarate hydratase -
CRN29_RS04170 839681..840511 - 831 WP_049306969.1 RluA family pseudouridine synthase -
CRN29_RS04175 840687..841799 + 1113 WP_030063524.1 GAF domain-containing sensor histidine kinase -
CRN29_RS04180 841819..842442 + 624 WP_023350050.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 7012.37 Da        Isoelectric Point: 3.8420

>T86540 WP_023350045.1 NZ_CP023966:837280-837459 [Staphylococcus capitis]
MNKEYESKLNYHEEENAMVTDLDDLKELGKEMEQISEENDEDKLNQSHDEDVHSDLNNE

Download         Length: 180 bp

>T86540 NZ_CP023966:837280-837459 [Staphylococcus capitis]
ATGAATAAAGAATATGAATCTAAATTGAATTATCATGAAGAAGAAAATGCTATGGTTACAGATTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAAATTTCAGAAGAAAATGATGAAGATAAATTAAACCAATCTCATGATGAAGATGTTCATT
CTGACCTTAATAATGAATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22720.63 Da        Isoelectric Point: 4.7928

>AT86540 WP_002453580.1 NZ_CP023966:836653-837252 [Staphylococcus capitis]
MAMNFKVFENSERVAEYAADIIRKQFNNNPTTIAGFHLEKDHAPVLDELKKNVDTHAVDFSQINILDYDDNRSYYEALGV
PESQVYSISYEQDAIDFISDKMKTKENKGKLILQVLSIDESGKLDVSVRQGLMEAREIFLVVTGSNKREVIEKLYRENGK
SSYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARYV

Download         Length: 600 bp

>AT86540 NZ_CP023966:836653-837252 [Staphylococcus capitis]
ATGGCAATGAACTTTAAAGTATTTGAAAATAGTGAAAGAGTAGCAGAATATGCTGCAGATATTATTCGTAAACAATTTAA
TAATAATCCAACTACAATTGCAGGTTTTCACTTAGAAAAAGATCACGCACCTGTATTAGATGAACTTAAGAAAAATGTAG
ATACGCATGCTGTAGATTTCAGCCAAATCAATATTTTAGATTATGATGATAATAGATCTTATTATGAAGCATTAGGTGTA
CCTGAAAGCCAAGTGTATTCAATTTCTTACGAACAAGATGCAATTGATTTTATTTCAGATAAAATGAAAACTAAAGAAAA
TAAAGGTAAATTAATCCTTCAAGTTCTTTCAATTGATGAAAGTGGCAAGTTAGATGTAAGTGTACGTCAAGGCCTTATGG
AAGCTAGAGAAATTTTCTTAGTTGTTACAGGTAGTAATAAACGTGAAGTTATTGAAAAACTTTATCGTGAAAACGGCAAA
TCTAGTTATGAGCCAGCAGATCTTAAAGCACACCGCATGGTAAATGTTATTTTAGATAAAGAAGCGGCTGCAGGATTACC
TGAGGATGTTAAAGAATACTTCACAGCACGTTATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A507SPY8

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4ECT8

References