86539

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 693923..694446 Replicon chromosome
Accession NZ_CP023966
Organism Staphylococcus capitis strain FDAARGOS_378

Toxin (Protein)


Gene name mazF Uniprot ID A0A1J4E8Y2
Locus tag CRN29_RS03355 Protein ID WP_002435799.1
Coordinates 694090..694446 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1J4E747
Locus tag CRN29_RS03350 Protein ID WP_002435513.1
Coordinates 693923..694093 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN29_RS03325 689750..690229 + 480 WP_023351370.1 PH domain-containing protein -
CRN29_RS03330 690222..691721 + 1500 WP_030063298.1 PH domain-containing protein -
CRN29_RS03335 691714..692214 + 501 WP_023351372.1 PH domain-containing protein -
CRN29_RS03340 692263..692619 + 357 WP_002435510.1 holo-ACP synthase -
CRN29_RS03345 692686..693834 + 1149 WP_023351373.1 alanine racemase -
CRN29_RS03350 693923..694093 + 171 WP_002435513.1 hypothetical protein Antitoxin
CRN29_RS03355 694090..694446 + 357 WP_002435799.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CRN29_RS03360 694825..695826 + 1002 WP_030063302.1 PP2C family protein-serine/threonine phosphatase -
CRN29_RS03365 695928..696254 + 327 WP_002435753.1 anti-sigma factor antagonist -
CRN29_RS03370 696256..696735 + 480 WP_002435518.1 anti-sigma B factor RsbW -
CRN29_RS03375 696710..697480 + 771 WP_002435824.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13327.44 Da        Isoelectric Point: 9.8770

>T86539 WP_002435799.1 NZ_CP023966:694090-694446 [Staphylococcus capitis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALDISLGLHNFDHQ

Download         Length: 357 bp

>T86539 NZ_CP023966:694090-694446 [Staphylococcus capitis]
ATGATTAGAAGAGGCGATGTTTACTTAGCTGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTTGT
AATTATACAAAATGATACTGGTAATAAATATAGTCCAACTGTCATAGTTGCTGCTATTACAGGTAGGATTAATAAAGCGA
AGATACCAACCCATGTAGAAATTGAAAAGAAAAAATATAAGTTAGATAAAGACTCTGTTATCTTACTTGAACAAATTAGA
ACACTAGATAAAAAACGTTTAAAAGAGAAGTTGACCTATTTGTCTGAAAGTAAGATGAAGGAAGTTGACAACGCCCTAGA
TATCAGTCTAGGATTACATAATTTTGACCATCAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6263.87 Da        Isoelectric Point: 4.0121

>AT86539 WP_002435513.1 NZ_CP023966:693923-694093 [Staphylococcus capitis]
MLSFNQSRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNSKNE

Download         Length: 171 bp

>AT86539 NZ_CP023966:693923-694093 [Staphylococcus capitis]
ATGTTATCTTTTAATCAATCTAGGAGTCACAGTCTTGAACAATCATTAAAAGAAGGCTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACGGAAGCTTTTCCCATCGAATGTGAAGCTTGCGATTGTAATGAAACATATCTTACTTCTAACTCTA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4E8Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4E747

References