Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 682887..683401 Replicon chromosome
Accession NZ_CP023966
Organism Staphylococcus capitis strain FDAARGOS_378

Toxin (Protein)


Gene name TsdT Uniprot ID A0A1J4E3P3
Locus tag CRN29_RS03295 Protein ID WP_023351364.1
Coordinates 683195..683401 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1J4E888
Locus tag CRN29_RS03290 Protein ID WP_002435858.1
Coordinates 682887..683180 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN29_RS03265 678045..678833 + 789 WP_023351361.1 hydroxyethylthiazole kinase -
CRN29_RS03270 678840..679478 + 639 WP_023351362.1 thiamine phosphate synthase -
CRN29_RS03275 679567..680439 + 873 WP_002435877.1 membrane protein insertase YidC -
CRN29_RS03280 680498..681160 - 663 WP_023351363.1 HD domain-containing protein -
CRN29_RS03285 681217..682701 - 1485 WP_002435854.1 cardiolipin synthase -
CRN29_RS03290 682887..683180 + 294 WP_002435858.1 copper-sensing transcriptional repressor CsoR Antitoxin
CRN29_RS03295 683195..683401 + 207 WP_023351364.1 hypothetical protein Toxin
CRN29_RS03300 683538..683675 + 138 WP_002435861.1 hypothetical protein -
CRN29_RS03305 683731..684942 - 1212 WP_023351365.1 rod shape-determining protein RodA -
CRN29_RS03310 685347..686417 + 1071 WP_002435813.1 D-alanine--D-alanine ligase -
CRN29_RS03315 686433..687788 + 1356 WP_023351368.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7821.85 Da        Isoelectric Point: 4.2087

>T86538 WP_023351364.1 NZ_CP023966:683195-683401 [Staphylococcus capitis]
MENGIVYVANIETIEEENQLKTRLENMIGVEKVDIDSKVGEIKVLFETPANLNSIEKEVYDSGFRVRY

Download         Length: 207 bp

>T86538 NZ_CP023966:683195-683401 [Staphylococcus capitis]
ATGGAAAATGGAATTGTTTATGTTGCTAATATTGAGACTATAGAGGAAGAAAACCAATTAAAGACACGTTTAGAAAATAT
GATTGGTGTCGAAAAAGTAGATATTGATAGTAAAGTAGGAGAAATAAAGGTATTATTTGAAACGCCTGCGAATTTAAATA
GTATTGAAAAAGAAGTATATGATTCTGGCTTTCGCGTGCGTTATTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11065.56 Da        Isoelectric Point: 6.4776

>AT86538 WP_002435858.1 NZ_CP023966:682887-683180 [Staphylococcus capitis]
VTENETAHHSEQTKANLKSRLNRIEGQVRAINRMIEDDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMNKVNNGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT86538 NZ_CP023966:682887-683180 [Staphylococcus capitis]
GTGACTGAAAATGAAACTGCACATCACTCAGAGCAAACGAAAGCAAATTTAAAGTCACGATTAAATCGTATCGAAGGTCA
AGTACGTGCAATTAATCGAATGATTGAAGACGATGTGTATTGCGATGATGTTTTAACTCAAATAAGAGCGACACGCTCTG
CTTTAAACAGTGTGGCTACTAAATTGTTAGATCATCATATGAAAAGTTGTATTATGAATAAAGTGAATAATGGTGCACAA
GAAGAAGCGATGGAAGAACTATTGGTTACTTTTCAAAAATTAATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4E3P3

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4E888

References