Detailed information of TA system TA086537

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/GNAT-DUF1778
• Location: 2396375..2397120
• Replicon: chromosome
• Accession: NZ_CP023965
• Organism: Proteus vulgaris strain FDAARGOS_366

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: CRN77_RS10680
• Protein ID: WP_075673025.1
• Coordinates: 2396375..2396866 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: CRN77_RS10685
• Protein ID: WP_075673024.1
• Coordinates: 2396854..2397120 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRN77_RS10660	2391466..2392572	+	1107	WP_098942422.1	flagellar basal body P-ring protein FlgI	-
CRN77_RS10665	2392572..2393558	+	987	WP_098942423.1	flagellar assembly peptidoglycan hydrolase FlgJ	-
CRN77_RS10670	2393677..2395320	+	1644	WP_098942424.1	flagellar hook-associated protein FlgK	-
CRN77_RS10675	2395345..2396289	+	945	WP_098942425.1	flagellar hook-associated protein FlgL	-
CRN77_RS10680	2396375..2396866	-	492	WP_075673025.1	GNAT family N-acetyltransferase	Toxin
CRN77_RS10685	2396854..2397120	-	267	WP_075673024.1	DUF1778 domain-containing protein	Antitoxin
CRN77_RS10690	2397244..2398026	-	783	WP_098942426.1	flagellar type III secretion system protein FliR	-
CRN77_RS10695	2398032..2398301	-	270	WP_098942427.1	flagellar biosynthesis protein FliQ	-
CRN77_RS10700	2398317..2399030	-	714	WP_171455369.1	flagellar type III secretion system pore protein FliP	-
CRN77_RS10705	2399087..2399533	-	447	WP_098942428.1	flagellar biosynthetic protein FliO	-
CRN77_RS10710	2399537..2399947	-	411	WP_023581830.1	flagellar motor switch protein FliN	-
CRN77_RS10715	2399940..2400971	-	1032	WP_023581831.1	flagellar motor switch protein FliM	-
CRN77_RS10720	2400977..2401459	-	483	WP_006533151.1	flagellar basal body-associated protein FliL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (22-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-87)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18228.15 Da
• Isoelectric Point: 10.3194

>T86537 WP_075673025.1 NZ_CP023965:c2396866-2396375 [Proteus vulgaris]
MGKVTAPEPLSNSHEVADFYSSENVLDNWIKQRGLKNQFLGASRTFVVCEKNKKRVVGYYSLATGSVNHTEAMSHIRRNM
PDPIPVIILARLAVDKTFHGKGLGADLLRDAVLRCHHVAENIGVRAIMVHALTENAKHFYLHHGFKASSTQDKILFLALK
KKI

Nucleotide

• Length: 492 bp

>T86537 NZ_CP023965:c2396866-2396375 [Proteus vulgaris]
ATGGGAAAAGTAACAGCACCTGAGCCGTTATCAAACTCACATGAAGTGGCTGATTTTTATAGTAGTGAAAATGTATTAGA
TAACTGGATAAAACAAAGAGGTTTAAAAAACCAATTTTTAGGTGCATCCCGTACATTTGTGGTCTGTGAAAAAAATAAAA
AACGTGTTGTTGGGTACTATTCTTTAGCAACAGGTAGTGTTAACCATACTGAAGCAATGAGTCATATTCGTCGCAATATG
CCAGACCCAATACCCGTGATCATTTTAGCTAGACTTGCTGTTGATAAAACTTTTCATGGAAAAGGTCTTGGTGCCGATTT
GTTAAGAGATGCAGTTTTGCGTTGTCATCATGTAGCTGAAAACATTGGTGTTAGAGCGATTATGGTTCATGCTTTAACTG
AAAACGCAAAACATTTCTACCTTCATCATGGTTTCAAAGCTTCTTCGACTCAAGACAAAATCTTATTCTTAGCACTAAAA
AAGAAAATATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10111.62 Da
• Isoelectric Point: 4.5256

>AT86537 WP_075673024.1 NZ_CP023965:c2397120-2396854 [Proteus vulgaris]
MKADVQLNIRAKESQRALIDTAAEILHKSRTDFILETACQAAEDVILDRRTFNLNDAQYAEFIEIIDAPVDIDPALEKLL
MRKPLWEK

Nucleotide

• Length: 267 bp

>AT86537 NZ_CP023965:c2397120-2396854 [Proteus vulgaris]
ATGAAAGCTGATGTACAACTCAATATTCGCGCTAAAGAATCACAACGCGCACTTATTGATACTGCTGCTGAAATTCTCCA
TAAATCTCGTACTGACTTTATTCTTGAGACAGCATGCCAAGCTGCTGAAGACGTCATTTTAGACCGTAGAACCTTTAATT
TAAATGATGCTCAATATGCGGAATTTATAGAAATTATTGATGCGCCGGTTGATATTGACCCTGCTCTTGAAAAGTTATTA
ATGAGAAAACCATTATGGGAAAAGTAA