Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1489908..1491655 Replicon chromosome
Accession NZ_CP023965
Organism Proteus vulgaris strain FDAARGOS_366

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CRN77_RS06665 Protein ID WP_098941872.1
Coordinates 1490282..1491655 (-) Length 458 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CRN77_RS06660 Protein ID WP_098941871.1
Coordinates 1489908..1490285 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN77_RS06635 1485808..1487541 + 1734 WP_075673441.1 hydrogenase large subunit -
CRN77_RS06640 1487553..1488107 + 555 WP_075673442.1 hydrogenase 4 subunit H -
CRN77_RS06645 1488104..1488886 + 783 WP_072069032.1 NADH-quinone oxidoreductase subunit B family protein -
CRN77_RS06650 1488879..1489289 + 411 WP_088494545.1 formate hydrogenlyase maturation HycH family protein -
CRN77_RS06655 1489286..1489786 + 501 WP_098941870.1 hydrogenase maturation peptidase HycI -
CRN77_RS06660 1489908..1490285 - 378 WP_098941871.1 helix-turn-helix domain-containing protein Antitoxin
CRN77_RS06665 1490282..1491655 - 1374 WP_098941872.1 type II toxin-antitoxin system HipA family toxin Toxin
CRN77_RS06670 1492038..1493027 + 990 WP_098941873.1 glycosyltransferase -
CRN77_RS06675 1493441..1495024 + 1584 WP_098941874.1 ABC transporter substrate-binding protein -
CRN77_RS06680 1495009..1495992 + 984 WP_098941875.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-418)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-103)


Sequences

Toxin        


Download         Length: 458 a.a.        Molecular weight: 52589.44 Da        Isoelectric Point: 4.6415

>T86536 WP_098941872.1 NZ_CP023965:c1491655-1490282 [Proteus vulgaris]
MEKITLQAFLNQEWVDIAIINFPKYDRMLYASKYDITYPITELEYETSYSIEHLYQDDQHAVSINHPVELYFDDSGSPGW
LKFLDDIVPSGASRRYWLQYLDIAELSTEQQNYELLHHGTISPIGNLRVKESLPAPSPLNRNLFFTINDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCNDNEEVWIDTYQDDISNLDKYYLVKFPRGSRSVVDCNILRTEYHFYHELTDMGFD
TIPIKDMRLEEGDNYPSLWLPRFDIKIENNKIIRLAMESVYSILNKAPGTTLYHETVIKELIDKINQSNMVTEFGFQFNT
ANFIIEWVRRDLLNIIFGNSDNHGRNTSLIRYNNAIYLAPIYDFAPMKADPEGIARTTKWGSHSEIGGEYNFINIADSLS
DLIAPEQLLNALQETAQQLLTLKERLEMRGVPTQILTMPSFGFDFIPNKLERWGLLP

Download         Length: 1374 bp

>T86536 NZ_CP023965:c1491655-1490282 [Proteus vulgaris]
ATGGAAAAGATAACATTACAAGCTTTCCTGAACCAAGAATGGGTAGATATTGCCATTATTAATTTTCCTAAGTATGACCG
TATGTTATATGCCAGTAAATATGATATTACTTATCCAATTACTGAGTTGGAATATGAAACAAGTTATTCAATAGAGCATC
TTTATCAAGATGATCAACATGCCGTTTCTATTAATCATCCTGTTGAACTTTATTTTGATGATAGTGGCTCACCTGGCTGG
CTTAAATTCTTAGATGATATTGTGCCTAGTGGAGCAAGTCGACGATATTGGCTCCAATATCTTGATATTGCTGAACTTAG
CACTGAGCAACAAAATTATGAATTACTTCATCACGGTACTATTTCTCCCATTGGAAACTTAAGAGTAAAAGAGTCATTAC
CCGCACCGTCTCCCTTAAATAGAAATCTTTTTTTCACTATTAATGATGTAAAGAATCGTGCGAGTGACTTTTTAGATTAT
GCTCAACGTAAAGGAGCGGCAGCTGGTGGTGCAACAGGTGCTGGAGGTGAGGCCCCCAAATTATTATTAAGGTGCAATGA
TAATGAGGAAGTTTGGATTGATACTTATCAAGACGATATATCTAATCTTGATAAATATTATTTAGTTAAATTTCCTAGAG
GGAGCCGTTCAGTTGTAGATTGTAATATTTTAAGAACAGAATATCATTTTTATCATGAACTTACAGATATGGGATTCGAT
ACGATCCCAATTAAAGATATGCGTTTAGAAGAAGGTGATAATTATCCTTCTTTATGGTTACCTCGGTTTGATATAAAAAT
AGAAAATAATAAAATTATTCGTTTAGCTATGGAGTCTGTCTATTCCATATTGAATAAAGCACCAGGTACAACTCTATATC
ATGAAACTGTTATCAAAGAATTAATAGATAAAATTAACCAAAGCAATATGGTTACTGAGTTTGGTTTTCAATTTAATACG
GCAAATTTTATTATCGAGTGGGTAAGGCGAGATTTATTAAATATTATTTTTGGTAATAGTGATAATCATGGGCGAAATAC
TTCTTTAATAAGATATAACAACGCAATTTATCTCGCACCTATTTATGATTTTGCACCGATGAAAGCGGATCCAGAAGGTA
TTGCTAGAACGACAAAATGGGGCTCTCACAGTGAAATTGGCGGCGAGTACAATTTTATTAATATCGCAGATTCTTTATCT
GATTTAATAGCACCAGAACAATTACTTAATGCATTACAAGAAACAGCACAACAATTGCTGACTTTAAAAGAAAGATTAGA
AATGAGGGGTGTACCTACGCAAATTTTAACCATGCCTTCATTTGGCTTTGATTTCATACCTAACAAATTAGAACGCTGGG
GATTATTACCATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14108.43 Da        Isoelectric Point: 10.5220

>AT86536 WP_098941871.1 NZ_CP023965:c1490285-1489908 [Proteus vulgaris]
MNNVENKNHIDKFPTRASRKHQFVATTDRKQVISKIMAHLLFGEITQGEALKMLRIKVLGLNQDLYAKLINVSRKTLSEI
ENDRGNYSADIINKVFKPFGLKVGLVPSSPHILSSLLKESPPINE

Download         Length: 378 bp

>AT86536 NZ_CP023965:c1490285-1489908 [Proteus vulgaris]
ATGAACAATGTTGAAAATAAAAATCACATAGATAAATTTCCCACCAGAGCTTCTAGAAAGCATCAGTTTGTAGCAACAAC
TGATAGAAAACAAGTTATTAGCAAGATCATGGCACATCTGTTATTCGGAGAAATAACTCAAGGAGAAGCATTGAAAATGT
TAAGGATTAAAGTTCTAGGTTTGAATCAAGATCTTTATGCAAAACTCATCAATGTTTCACGTAAAACCTTGTCTGAAATA
GAAAATGATAGAGGTAATTACTCTGCTGATATCATTAATAAAGTATTCAAACCTTTTGGCTTAAAAGTAGGACTTGTTCC
TTCTTCACCACATATTTTATCTTCACTATTAAAAGAATCCCCTCCAATTAATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References