Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 896008..897579 Replicon chromosome
Accession NZ_CP023965
Organism Proteus vulgaris strain FDAARGOS_366

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CRN77_RS04085 Protein ID WP_098941509.1
Coordinates 896266..897579 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CRN77_RS04080 Protein ID WP_072070485.1
Coordinates 896008..896265 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN77_RS04055 891978..892121 + 144 WP_004246509.1 50S ribosomal protein L34 -
CRN77_RS04060 892139..892498 + 360 WP_071788569.1 ribonuclease P protein component -
CRN77_RS04065 892462..892722 + 261 WP_072064717.1 membrane protein insertion efficiency factor YidD -
CRN77_RS04070 892725..894365 + 1641 WP_098941508.1 membrane protein insertase YidC -
CRN77_RS04075 894495..895859 + 1365 WP_023583363.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
CRN77_RS04080 896008..896265 + 258 WP_072070485.1 helix-turn-helix domain-containing protein Antitoxin
CRN77_RS04085 896266..897579 + 1314 WP_098941509.1 type II toxin-antitoxin system HipA family toxin Toxin
CRN77_RS04100 898588..899049 + 462 WP_098941511.1 DUF1097 domain-containing protein -
CRN77_RS04105 899150..899929 - 780 WP_098941512.1 ABC transporter ATP-binding protein -
CRN77_RS04110 900010..902091 - 2082 WP_098941513.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49636.50 Da        Isoelectric Point: 5.8274

>T86533 WP_098941509.1 NZ_CP023965:896266-897579 [Proteus vulgaris]
MASLDVYMNEYYVGIFTKKSSGAHSFQYAEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNPEIRNRIVSRYN
ANSNQPFDLLTAVGADTVGALRLLPSSSTPANIKKIEYNKLDNAELEKILLGYQSNTPLGMLEEYTDFRISIAGAQEKTA
LLLKDDHWCVPHNNTPTTHIIKLPIGVIEGHSYTMDLSDSVENEYLCTLIAKEFDLPVPHCFIVKTENIKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMNYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLQASRGKKYAIEQIFPRHFYQTAEAASFDPSLMTDILRYFYKEM
DDAIKRVKQQLPDDFPSEISSKILNGMKTRSARLANI

Download         Length: 1314 bp

>T86533 NZ_CP023965:896266-897579 [Proteus vulgaris]
ATGGCGAGCCTTGATGTGTATATGAATGAATATTATGTGGGTATTTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATGCTGAAGATTGGGTTAATCAACCAGGAAGTCGCCCTATATCTCTTTCTATGCCACTACAACTTCAAGAATATCAAG
GAGATTGTGTCTATAATTTCTTTGATAATCTTTTACCTGATAATCCTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCAAACTCAAATCAACCATTTGATCTATTAACTGCCGTGGGTGCAGATACGGTTGGTGCATTACGGTTACTTCCTAGTAG
TAGTACGCCAGCTAATATAAAAAAAATAGAATATAACAAACTTGATAACGCTGAACTTGAAAAAATACTATTAGGATATC
AATCCAATACACCACTCGGTATGCTTGAAGAATATACTGATTTCAGAATTTCTATCGCTGGAGCGCAAGAAAAAACAGCA
TTACTTTTAAAAGATGATCATTGGTGTGTGCCACACAATAATACGCCGACTACACATATTATTAAGCTACCCATTGGTGT
TATTGAAGGGCATTCCTATACAATGGATTTATCCGATAGTGTAGAAAATGAATATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCTGTTCCTCACTGTTTTATTGTTAAAACAGAAAATATTAAAGCGCTTGCTGTAGAACGCTTTGATAGAAAA
TACTCATCAGATAAATCGTGGATAATCCGCTTACCCCAAGAAGATTTTTGCCAAATTCTAAATATACCTTCAGCTCTAAA
ATATGAAAATGAAGGGGGGCCTGGCATTATTGATATCATGAATTATTTGCTTGGTTCATCAAATGCTGATCAAGACCGTT
TTCATTTTATGAAGGCACAAGTACTATTTTGGCTTTTAGCTGCAACAGATGGGCATGCAAAGAATTTCTCTGTTTTTATC
AATCAAGAAGGACGTTTTCACCTCACGCCTCTTTATGACATCATGTCTATCTATCCCAATTTTGGAGGACGAGGACTTAA
TCCACGAGATGCAAAACTCGCTATGGGATTACAGGCAAGCCGAGGCAAAAAATATGCCATAGAGCAAATTTTTCCTCGCC
ATTTTTACCAAACAGCTGAAGCAGCCAGTTTCGATCCTTCATTGATGACTGATATTCTTCGTTATTTTTATAAAGAAATG
GACGATGCCATCAAGCGCGTAAAACAACAACTACCTGATGATTTTCCTTCTGAAATTAGCAGTAAAATATTGAATGGAAT
GAAAACACGCTCTGCAAGATTAGCCAATATTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9848.40 Da        Isoelectric Point: 10.0139

>AT86533 WP_072070485.1 NZ_CP023965:896008-896265 [Proteus vulgaris]
MIIINAYQLSVHLKDVRLTKKLSQGKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp

>AT86533 NZ_CP023965:896008-896265 [Proteus vulgaris]
ATGATTATAATTAACGCCTATCAACTCAGCGTCCATCTAAAAGATGTCCGATTAACAAAAAAACTTTCTCAAGGTAAAGT
CGCCCAAAAAGTGGGAATTCGACAAGACACCGTGTCCAATTTTGAACTTAATCCTAATTCCACCAAGCTAGAAACCTTTT
TTAAACTGCTCTCCGCACTAAATTTAGAGATGGAAATTCATCCTAAAGATGCTAAAAATAATTTAGCACACAAAAGTGAA
TGGAAAGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References