Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4296765..4297531 Replicon chromosome
Accession NZ_CP023964
Organism Yersinia frederiksenii strain FDAARGOS_418

Toxin (Protein)


Gene name ypjF Uniprot ID A0A380PXI9
Locus tag CRN75_RS19600 Protein ID WP_004707125.1
Coordinates 4296765..4297133 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A380PXD3
Locus tag CRN75_RS19605 Protein ID WP_004707124.1
Coordinates 4297196..4297531 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN75_RS19585 4292238..4293554 - 1317 WP_032910486.1 McrC family protein -
CRN75_RS19590 4293551..4295614 - 2064 WP_032910485.1 McrB family protein -
CRN75_RS19595 4295803..4296633 - 831 WP_004707126.1 DUF4942 domain-containing protein -
CRN75_RS19600 4296765..4297133 - 369 WP_004707125.1 TA system toxin CbtA family protein Toxin
CRN75_RS19605 4297196..4297531 - 336 WP_004707124.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CRN75_RS19610 4297542..4298021 - 480 WP_004707123.1 DNA repair protein RadC -
CRN75_RS19615 4298204..4298824 - 621 WP_032910484.1 hypothetical protein -
CRN75_RS19620 4298852..4299406 - 555 WP_004707121.1 hypothetical protein -
CRN75_RS19625 4299654..4300409 - 756 WP_004707120.1 50S ribosome-binding GTPase -
CRN75_RS19630 4300597..4301493 - 897 WP_004707119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13734.81 Da        Isoelectric Point: 6.2158

>T86532 WP_004707125.1 NZ_CP023964:c4297133-4296765 [Yersinia frederiksenii]
MQTLPITLKRAAYACPSPVVVWQSMLTYLLEQHYGLVLSDTEFSDDAVIHEHIDAGISLADALNFTVEKFDLVRIDRRGF
SCQEQSPFITAIDILRARRATGLMARMGYQTITSVIRGEKQT

Download         Length: 369 bp

>T86532 NZ_CP023964:c4297133-4296765 [Yersinia frederiksenii]
ATGCAGACCTTACCTATCACCCTGAAACGGGCGGCCTACGCTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTCAC
GTATCTGTTAGAGCAGCATTACGGCCTGGTGCTGAGTGACACCGAGTTCAGTGATGACGCCGTTATCCACGAACATATTG
ATGCCGGTATCTCTCTGGCTGATGCGTTAAATTTTACGGTGGAAAAGTTCGACCTGGTTCGCATCGATCGCCGGGGATTC
TCCTGCCAGGAACAATCTCCTTTCATCACGGCTATCGATATTCTCCGTGCCCGTCGAGCCACTGGCCTGATGGCCCGTAT
GGGTTACCAGACTATCACCTCAGTTATCCGGGGCGAAAAGCAGACATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12341.99 Da        Isoelectric Point: 6.6316

>AT86532 WP_004707124.1 NZ_CP023964:c4297531-4297196 [Yersinia frederiksenii]
MPSITTPAWGLKRNVTPQLGARLVQEGDQLHFLADRADISGKFSDAQVRDLNNAFPQFINHLELMLLSGELNPRYQHCVT
LYHKGLTCEADSLGSHGYVYLAIYPTPQSTA

Download         Length: 336 bp

>AT86532 NZ_CP023964:c4297531-4297196 [Yersinia frederiksenii]
ATGCCATCAATCACTACCCCAGCCTGGGGACTTAAACGCAACGTCACTCCGCAGTTGGGTGCCCGTCTGGTACAGGAAGG
CGACCAGCTGCATTTTCTGGCCGACCGTGCCGATATCAGCGGGAAATTCAGTGACGCGCAGGTACGTGATTTAAATAACG
CCTTCCCGCAGTTTATCAACCACCTGGAACTGATGCTGCTCTCCGGTGAACTCAATCCACGTTATCAACACTGCGTCACG
CTCTACCACAAGGGACTAACCTGTGAAGCCGATAGTCTGGGTTCACACGGTTATGTGTATCTCGCCATTTATCCTACACC
CCAATCAACAGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380PXI9

Antitoxin

Source ID Structure
AlphaFold DB A0A380PXD3

References