Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3640709..3641327 Replicon chromosome
Accession NZ_CP023964
Organism Yersinia frederiksenii strain FDAARGOS_418

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag CRN75_RS16755 Protein ID WP_002208622.1
Coordinates 3641124..3641327 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A857F2E4
Locus tag CRN75_RS16750 Protein ID WP_004392643.1
Coordinates 3640709..3641077 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN75_RS16720 3636391..3636651 + 261 WP_004707629.1 type B 50S ribosomal protein L31 -
CRN75_RS16725 3636667..3636810 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
CRN75_RS16730 3636939..3637817 - 879 WP_004707627.1 metal ABC transporter substrate-binding protein -
CRN75_RS16735 3637846..3638703 - 858 WP_032910680.1 metal ABC transporter permease -
CRN75_RS16740 3638700..3639434 - 735 WP_032910697.1 ABC transporter ATP-binding protein -
CRN75_RS16745 3640251..3640550 + 300 Protein_3225 hypothetical protein -
CRN75_RS16750 3640709..3641077 + 369 WP_004392643.1 Hha toxicity modulator TomB Antitoxin
CRN75_RS16755 3641124..3641327 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
CRN75_RS16760 3642124..3644925 - 2802 WP_138070085.1 inverse autotransporter beta domain-containing protein -
CRN75_RS16765 3645396..3646307 + 912 WP_004707615.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T86531 WP_002208622.1 NZ_CP023964:3641124-3641327 [Yersinia frederiksenii]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T86531 NZ_CP023964:3641124-3641327 [Yersinia frederiksenii]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAGCTAAGCGATGATGAGCTGGAATTGTTTTACTCAGCTGCAGACCATCGCTTAGCTGAACTCACGATGAATAAAC
TTTATGATAAAATTCCACCTACTGTTTGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14176.95 Da        Isoelectric Point: 4.5140

>AT86531 WP_004392643.1 NZ_CP023964:3640709-3641077 [Yersinia frederiksenii]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDGGDLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT86531 NZ_CP023964:3640709-3641077 [Yersinia frederiksenii]
ATGGATGAGTACTCACCTAAGCGGCATGACATTGCCCAATTGAAGTTTCTATGTGAGAGTTTGTATGATGAAGGCATTGC
AACCCTTGGTGATAGCCACCATGGTTGGGTAAATGATCCGACATCAGCGGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGCGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGATACATATACTCTGTTTAGTAGTTATGGGATCAATGATCCTGAATTGCGTCGCTGGCAAAAAACCAAAGAGCGTTT
ATTCAGACTTTTCTCAGGCGAGTACATCTGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A857F2E4

References