Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3640709..3641327 Replicon chromosome
Accession NZ_CP023964
Organism Yersinia frederiksenii strain FDAARGOS_418

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag CRN75_RS16755 Protein ID WP_002208622.1
Coordinates 3641124..3641327 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A857F2E4
Locus tag CRN75_RS16750 Protein ID WP_004392643.1
Coordinates 3640709..3641077 (+) Length 123 a.a.

Genomic Context

CRN75_RS16720CRN75_RS16725CRN75_RS16745CRN75_RS16750CRN75_RS16755CRN75_RS16765CRN75_RS16730CRN75_RS16735CRN75_RS16740CRN75_RS16760
Location: 3636391..3636651 (261 bp)
Type: Others
Protein ID: WP_004707629.1
Location: 3636667..3636810 (144 bp)
Type: Others
Protein ID: WP_002208618.1
Location: 3640251..3640550 (300 bp)
Type: Others
Protein ID: Protein_3225
Location: 3640709..3641077 (369 bp)
Type: Antitoxin
Protein ID: WP_004392643.1
Location: 3641124..3641327 (204 bp)
Type: Toxin
Protein ID: WP_002208622.1
Location: 3645396..3646307 (912 bp)
Type: Others
Protein ID: WP_004707615.1
Location: 3636939..3637817 (879 bp)
Type: Others
Protein ID: WP_004707627.1
Location: 3637846..3638703 (858 bp)
Type: Others
Protein ID: WP_032910680.1
Location: 3638700..3639434 (735 bp)
Type: Others
Protein ID: WP_032910697.1
Location: 3642124..3644925 (2802 bp)
Type: Others
Protein ID: WP_138070085.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CRN75_RS167203636391..3636651+261WP_004707629.1type B 50S ribosomal protein L31-
CRN75_RS167253636667..3636810+144WP_002208618.1type B 50S ribosomal protein L36-
CRN75_RS167303636939..3637817-879WP_004707627.1metal ABC transporter substrate-binding protein-
CRN75_RS167353637846..3638703-858WP_032910680.1metal ABC transporter permease-
CRN75_RS167403638700..3639434-735WP_032910697.1ABC transporter ATP-binding protein-
CRN75_RS167453640251..3640550+300Protein_3225hypothetical protein-
CRN75_RS167503640709..3641077+369WP_004392643.1Hha toxicity modulator TomBAntitoxin
CRN75_RS167553641124..3641327+204WP_002208622.1expression modulating protein YmoAToxin
CRN75_RS167603642124..3644925-2802WP_138070085.1inverse autotransporter beta domain-containing protein-
CRN75_RS167653645396..3646307+912WP_004707615.1LysR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T86531 WP_002208622.1 NZ_CP023964:3641124-3641327 [Yersinia frederiksenii]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T86531 NZ_CP023964:3641124-3641327 [Yersinia frederiksenii]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAGCTAAGCGATGATGAGCTGGAATTGTTTTACTCAGCTGCAGACCATCGCTTAGCTGAACTCACGATGAATAAAC
TTTATGATAAAATTCCACCTACTGTTTGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14176.95 Da        Isoelectric Point: 4.5140

>AT86531 WP_004392643.1 NZ_CP023964:3640709-3641077 [Yersinia frederiksenii]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDGGDLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT86531 NZ_CP023964:3640709-3641077 [Yersinia frederiksenii]
ATGGATGAGTACTCACCTAAGCGGCATGACATTGCCCAATTGAAGTTTCTATGTGAGAGTTTGTATGATGAAGGCATTGC
AACCCTTGGTGATAGCCACCATGGTTGGGTAAATGATCCGACATCAGCGGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGCGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGATACATATACTCTGTTTAGTAGTTATGGGATCAATGATCCTGAATTGCGTCGCTGGCAAAAAACCAAAGAGCGTTT
ATTCAGACTTTTCTCAGGCGAGTACATCTGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB2K5S

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A857F2E4

References