Detailed information of TA system TA086529

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2559834..2560830
• Replicon: chromosome
• Accession: NZ_CP023964
• Organism: Yersinia frederiksenii strain FDAARGOS_418

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A380PP72
• Locus tag: CRN75_RS11530
• Protein ID: WP_004706649.1
• Coordinates: 2560372..2560830 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A380PR35
• Locus tag: CRN75_RS11525
• Protein ID: WP_004706650.1
• Coordinates: 2559834..2560280 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRN75_RS11505	2555461..2556168	+	708	WP_032910203.1	murein tripeptide amidase MpaA	-
CRN75_RS11510	2556165..2557136	-	972	WP_032910202.1	L-Ala-D/L-Glu epimerase	-
CRN75_RS11515	2557289..2557792	+	504	WP_032910201.1	thiol peroxidase	-
CRN75_RS11520	2557938..2559515	-	1578	WP_032910200.1	transcriptional regulator TyrR	-
CRN75_RS11525	2559834..2560280	+	447	WP_004706650.1	DUF2384 domain-containing protein	Antitoxin
CRN75_RS11530	2560372..2560830	+	459	WP_004706649.1	RES family NAD+ phosphorylase	Toxin
CRN75_RS11535	2560857..2561921	-	1065	WP_032910198.1	YcjF family protein	-
CRN75_RS11540	2561918..2563315	-	1398	WP_032910196.1	YcjX family protein	-
CRN75_RS11545	2563296..2563535	-	240	WP_032910194.1	phage shock protein PspD	-
CRN75_RS11550	2563584..2563943	-	360	WP_004706642.1	envelope stress response membrane protein PspC	-
CRN75_RS11555	2563943..2564170	-	228	WP_032910193.1	envelope stress response membrane protein PspB	-
CRN75_RS11560	2564271..2564936	-	666	WP_004706639.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17145.46 Da
• Isoelectric Point: 4.7051

>T86529 WP_004706649.1 NZ_CP023964:2560372-2560830 [Yersinia frederiksenii]
MIFYRIVMRHYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLEALVHIQDSSTLSEFELFQIEIDDNNIMLLQPQ
DWPGDWRSDPAPVATMDIGTEWLESESSLGLLVPSSLVPSENNLLVNPRHKDFQACLSSVKPLSFTFDSRLK

Nucleotide

• Length: 459 bp

>T86529 NZ_CP023964:2560372-2560830 [Yersinia frederiksenii]
ATGATTTTTTACCGCATAGTGATGCGCCATTATCTGGCGTCAACCTGGACTGGCTACGGTGCGGAAATCTATGGTGGCCG
CTGGAATCACAAGGGACATGCGGCTATTTACTTAGCCAGCAGTGTGTCATTGGCGATGCTGGAAGCCTTAGTACATATTC
AGGACAGCTCGACACTGAGTGAGTTCGAACTATTCCAGATTGAGATCGATGACAATAATATCATGCTGCTACAACCACAG
GACTGGCCTGGTGATTGGCGCAGTGATCCGGCACCGGTGGCCACAATGGATATTGGCACCGAATGGCTGGAATCAGAATC
ATCACTTGGATTACTGGTTCCCTCTAGTCTGGTGCCATCAGAAAATAATCTGCTGGTTAACCCTCGCCACAAAGACTTTC
AAGCTTGCCTGAGCAGTGTCAAACCGCTCTCTTTTACCTTTGACTCGCGCCTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16296.70 Da
• Isoelectric Point: 9.1489

>AT86529 WP_004706650.1 NZ_CP023964:2559834-2560280 [Yersinia frederiksenii]
MRAYHPAPASKTGALWREIGLPASRGTVLVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKNRAITWMSTPIKGLGHRSPDSLLETETGALEVCDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT86529 NZ_CP023964:2559834-2560280 [Yersinia frederiksenii]
ATGAGAGCATATCACCCAGCTCCAGCGTCCAAAACAGGCGCGCTATGGCGTGAGATTGGTTTGCCCGCCAGCCGCGGCAC
CGTATTGGTAGACAGCATCAAGATGGGGTTTTCTGTTGATGTTATCGACAGTATTCATTTATGGGCATCGATGCCTAAAG
CCGAAATATTGCGTGCGACCGGTATTCCCAGCCGTAGTCTTACTCGTCGACGCACCCATGATGGCCGTTTTACACCAGAA
GAGAGTGAGCGAATTGCGCGTTTCGTCCGCGTAATGGATGCCGCAGTCGATTTGTTTGGCGGTGATAAAAACCGCGCTAT
CACCTGGATGTCTACCCCAATTAAAGGCTTAGGGCACCGCAGCCCTGACTCTCTGCTGGAAACAGAAACCGGTGCATTGG
AAGTCTGTGATTTAATCGGGCGACTGGAGCACGGCGTATTCTCATAG

Structures

Toxin

• AlphaFold DB: A0A380PP72

Antitoxin

• AlphaFold DB: A0A380PR35