Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 902853..903525 Replicon chromosome
Accession NZ_CP023964
Organism Yersinia frederiksenii strain FDAARGOS_418

Toxin (Protein)


Gene name cptA Uniprot ID A0A380PTX9
Locus tag CRN75_RS03915 Protein ID WP_032910283.1
Coordinates 903100..903525 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0T9TYF0
Locus tag CRN75_RS03910 Protein ID WP_004706797.1
Coordinates 902853..903119 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN75_RS03890 899185..899934 + 750 Protein_748 SDR family oxidoreductase -
CRN75_RS03895 899952..900554 - 603 WP_004706800.1 HD domain-containing protein -
CRN75_RS03900 900780..901463 + 684 WP_004706799.1 hemolysin III family protein -
CRN75_RS03905 901664..902647 - 984 WP_004706798.1 tRNA-modifying protein YgfZ -
CRN75_RS03910 902853..903119 + 267 WP_004706797.1 FAD assembly factor SdhE Antitoxin
CRN75_RS03915 903100..903525 + 426 WP_032910283.1 protein YgfX Toxin
CRN75_RS03920 903525..904223 + 699 WP_004706796.1 two-component system response regulator CreB -
CRN75_RS03925 904234..905661 + 1428 WP_004706795.1 two-component system sensor histidine kinase CreC -
CRN75_RS03930 905754..907175 + 1422 WP_032910280.1 cell envelope integrity protein CreD -
CRN75_RS03935 907227..907745 - 519 WP_032910279.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16411.24 Da        Isoelectric Point: 9.8616

>T86520 WP_032910283.1 NZ_CP023964:903100-903525 [Yersinia frederiksenii]
VAQWRCDLRVSWHTQLFSLLAHGVLVILTLVAPWPQGYTALWLVLLTLVVFECIRSQKNIRSCQGEIRLKPGNVVLWKRH
EWIIIKQPWITRYGVLLSLQQTGSRSARNRLWLAADSMSEEEWRQLCVLLRHAFGSDEGIH

Download         Length: 426 bp

>T86520 NZ_CP023964:903100-903525 [Yersinia frederiksenii]
GTGGCCCAGTGGCGATGTGACCTGCGGGTATCCTGGCACACTCAACTCTTCTCTTTATTGGCTCATGGCGTCTTAGTCAT
ACTGACATTAGTCGCACCTTGGCCTCAGGGCTATACCGCACTTTGGTTGGTATTACTGACGTTAGTGGTTTTTGAGTGTA
TCCGCAGCCAGAAAAATATTCGGTCCTGTCAGGGCGAGATTCGGCTGAAACCCGGCAATGTAGTGCTATGGAAAAGACAT
GAATGGATTATCATTAAACAGCCATGGATTACCCGTTATGGCGTGTTATTAAGTCTGCAACAGACTGGGAGTCGCTCGGC
CCGCAACCGTTTATGGCTGGCGGCTGATAGCATGTCGGAAGAGGAGTGGCGGCAACTGTGCGTACTGCTGCGTCATGCCT
TTGGCTCTGATGAGGGGATTCATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10487.02 Da        Isoelectric Point: 4.8551

>AT86520 WP_004706797.1 NZ_CP023964:902853-903119 [Yersinia frederiksenii]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQARN
KARGPVAM

Download         Length: 267 bp

>AT86520 NZ_CP023964:902853-903119 [Yersinia frederiksenii]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGGGGTATGCGGGAATTGGATATCTCTATCATGCCGTT
TTTCGAATATGAATATGATGGTTTAAGTGACAATGAGAAGCAGGTCTTTATTCGTCTACTTGAGTGTGATGATCCAGACT
TATTTAATTGGTTGATGAATCACGGGGAGCCGCAGGATAGCGAACTGCGTCAAATGGTCAAATTGATTCAAGCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380PTX9

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9TYF0

References