Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4460543..4461200 Replicon chromosome
Accession NZ_CP023963
Organism Klebsiella aerogenes strain FDAARGOS_363

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag CRN78_RS21885 Protein ID WP_015369792.1
Coordinates 4460543..4460953 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag CRN78_RS21890 Protein ID WP_015369791.1
Coordinates 4460934..4461200 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN78_RS21865 4456542..4458275 - 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -
CRN78_RS21870 4458281..4458994 - 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CRN78_RS21875 4459017..4459913 - 897 WP_045414365.1 site-specific tyrosine recombinase XerD -
CRN78_RS21880 4460014..4460535 + 522 WP_045387211.1 flavodoxin FldB -
CRN78_RS21885 4460543..4460953 - 411 WP_015369792.1 protein YgfX Toxin
CRN78_RS21890 4460934..4461200 - 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
CRN78_RS21895 4461424..4462407 + 984 WP_015369790.1 tRNA-modifying protein YgfZ -
CRN78_RS21900 4462506..4463165 - 660 WP_008806429.1 hemolysin III family protein -
CRN78_RS21905 4463330..4463641 - 312 WP_015369789.1 N(4)-acetylcytidine aminohydrolase -
CRN78_RS21910 4463692..4464420 + 729 WP_020077980.1 MurR/RpiR family transcriptional regulator -
CRN78_RS21915 4464540..4465973 + 1434 WP_086557610.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T86519 WP_015369792.1 NZ_CP023963:c4460953-4460543 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T86519 NZ_CP023963:c4460953-4460543 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTGATCGATTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGCATGGATGCGGGGGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCACGACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT86519 WP_015369791.1 NZ_CP023963:c4461200-4460934 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT86519 NZ_CP023963:c4461200-4460934 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References