Detailed information of TA system TA086507

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4814103..4815653
• Replicon: chromosome
• Accession: NZ_CP023962
• Organism: Yersinia frederiksenii strain FDAARGOS_417

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A0T9TNV2
• Locus tag: CRN74_RS22390
• Protein ID: WP_050080816.1
• Coordinates: 4814358..4815653 (+)
• Length: 432 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: CRN74_RS22385
• Protein ID: WP_050080817.1
• Coordinates: 4814103..4814354 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRN74_RS22360	4809508..4810104	+	597	WP_050080822.1	response regulator transcription factor	-
CRN74_RS22365	4810303..4810908	-	606	WP_050872449.1	response regulator transcription factor	-
CRN74_RS22375	4811329..4813065	-	1737	WP_098905182.1	SulP family inorganic anion transporter	-
CRN74_RS22380	4813150..4813986	-	837	WP_098905321.1	3'-kinase	-
CRN74_RS22385	4814103..4814354	+	252	WP_050080817.1	helix-turn-helix domain-containing protein	Antitoxin
CRN74_RS22390	4814358..4815653	+	1296	WP_050080816.1	type II toxin-antitoxin system HipA family toxin	Toxin
CRN74_RS22395	4815817..4816299	-	483	WP_098905183.1	DUF2501 domain-containing protein	-
CRN74_RS22400	4816540..4816830	-	291	WP_019211216.1	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase	-
CRN74_RS22405	4816851..4817726	-	876	WP_019211215.1	3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase	-
CRN74_RS22410	4817782..4818801	-	1020	WP_019211214.1	autoinducer 2 ABC transporter substrate-binding protein LsrB	-
CRN74_RS22415	4818882..4819883	-	1002	WP_019211213.1	autoinducer 2 ABC transporter permease LsrD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 432 a.a.
• Molecular weight: 48487.86 Da
• Isoelectric Point: 6.5940

>T86507 WP_050080816.1 NZ_CP023962:4814358-4815653 [Yersinia frederiksenii]
MEKLTLALNGIVVGTLEKAAGGEISFFYHDSWLERSGARAISLSLPLQTVKFRGEVVYNFFDNLLPDSESIRSRIQARFQ
TPTKQPFDLLSQIGSDCVGAIQLYPEGRQINSVTEIHATPLNDNEIEKLLLGYKEAPLGMEADIDDFRISLAGAQEKTAL
LWYQNQWHRPEGSTPTSHILKLPIGYIAANGIDLSESVENEWLCLKIAEEFGLPVAYSEIKYFGKQKALVVERFDRRWSP
NNSWLMRLPQEDFCQVLGVAPALKYESDGGPGIADAMKLLLGSQQAIQDRDIFFKSQILFWMLAAIDGHAKNFSVFIELD
SAFRMTPIYDVMSAFPLMHPRGIPAKKAKMAMALLGRNRHFHWSTILPRHFISTAKQVNYPEDNVVQLMAEMKEKTEQVI
AAVKAVLPQGFPEKISEPIFSGLRRQSAKLP

Nucleotide

• Length: 1296 bp

>T86507 NZ_CP023962:4814358-4815653 [Yersinia frederiksenii]
ATGGAAAAGTTAACCCTTGCATTAAACGGCATCGTAGTTGGTACCTTGGAGAAGGCTGCCGGTGGTGAAATCTCTTTTTT
CTATCATGATAGCTGGCTTGAACGCAGTGGAGCACGTGCGATTTCTCTGTCGTTACCCCTACAAACGGTGAAATTCCGTG
GGGAGGTTGTTTATAATTTTTTTGATAACCTTCTGCCTGACAGTGAATCTATTCGCAGCCGTATTCAAGCGCGTTTTCAA
ACACCAACAAAGCAACCTTTTGATTTACTCTCCCAAATAGGGAGTGATTGCGTAGGGGCAATTCAATTATACCCAGAAGG
CCGGCAAATAAATTCTGTCACCGAGATCCATGCAACGCCTTTAAATGACAATGAGATAGAAAAATTACTCTTAGGGTATA
AGGAGGCGCCTTTGGGCATGGAGGCCGATATTGATGATTTCCGTATTTCTTTGGCTGGGGCACAAGAGAAAACAGCCTTA
CTGTGGTATCAGAATCAATGGCATCGGCCAGAAGGGAGTACACCAACGAGTCATATTCTTAAATTGCCTATAGGCTATAT
AGCCGCTAATGGTATTGATTTAAGTGAAAGTGTCGAGAATGAATGGTTGTGCTTAAAGATTGCTGAAGAATTTGGTCTAC
CTGTCGCGTATTCAGAAATAAAATATTTTGGTAAGCAAAAGGCATTAGTTGTTGAGCGGTTCGATCGCCGCTGGAGCCCT
AATAATAGTTGGTTGATGCGTTTACCGCAGGAGGATTTTTGTCAGGTCTTAGGTGTAGCACCTGCACTCAAATATGAATC
TGATGGTGGTCCTGGGATTGCAGATGCGATGAAACTATTACTCGGTTCTCAGCAAGCGATTCAGGATCGGGATATTTTTT
TTAAAAGTCAGATACTTTTCTGGATGTTAGCCGCGATTGACGGGCACGCGAAGAATTTTAGTGTGTTTATTGAATTGGAT
AGCGCATTTCGTATGACACCCATTTACGATGTGATGTCTGCATTTCCACTCATGCACCCACGAGGAATACCGGCTAAAAA
AGCAAAAATGGCCATGGCATTACTTGGACGTAATCGGCATTTTCACTGGAGTACTATTTTACCTCGGCACTTCATTTCAA
CCGCGAAACAGGTGAATTATCCCGAAGATAATGTTGTGCAATTAATGGCTGAAATGAAAGAAAAAACCGAACAAGTGATA
GCTGCGGTGAAGGCGGTTCTACCACAGGGCTTTCCCGAAAAAATCAGTGAGCCTATTTTCTCTGGTTTAAGGCGGCAGTC
GGCGAAACTGCCCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9584.94 Da
• Isoelectric Point: 10.4866

>AT86507 WP_050080817.1 NZ_CP023962:4814103-4814354 [Yersinia frederiksenii]
MKITSAAMLANTLRNERKKSKLTQRKTAETVGLKQSTVSEFENHPDGTKLDTLFKLLAALDLELQVRPRNRNIKDNTTWD
QEW

Nucleotide

• Length: 252 bp

>AT86507 NZ_CP023962:4814103-4814354 [Yersinia frederiksenii]
ATGAAAATTACCTCTGCTGCAATGTTGGCAAATACACTACGGAATGAACGCAAAAAAAGTAAGCTGACTCAGCGAAAAAC
AGCCGAGACAGTCGGTTTGAAGCAATCAACAGTATCAGAGTTTGAAAACCATCCTGATGGTACCAAATTAGACACGCTGT
TTAAGTTATTGGCAGCACTGGATTTAGAGCTACAGGTTAGGCCAAGGAACCGCAATATTAAGGATAATACAACCTGGGAT
CAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A0T9TNV2