Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4814103..4815653 Replicon chromosome
Accession NZ_CP023962
Organism Yersinia frederiksenii strain FDAARGOS_417

Toxin (Protein)


Gene name hipA Uniprot ID A0A0T9TNV2
Locus tag CRN74_RS22390 Protein ID WP_050080816.1
Coordinates 4814358..4815653 (+) Length 432 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CRN74_RS22385 Protein ID WP_050080817.1
Coordinates 4814103..4814354 (+) Length 84 a.a.

Genomic Context

CRN74_RS22360CRN74_RS22385CRN74_RS22390CRN74_RS22365CRN74_RS22375CRN74_RS22380CRN74_RS22395CRN74_RS22400CRN74_RS22405CRN74_RS22410CRN74_RS22415
Location: 4809508..4810104 (597 bp)
Type: Others
Protein ID: WP_050080822.1
Location: 4814103..4814354 (252 bp)
Type: Antitoxin
Protein ID: WP_050080817.1
Location: 4814358..4815653 (1296 bp)
Type: Toxin
Protein ID: WP_050080816.1
Location: 4810303..4810908 (606 bp)
Type: Others
Protein ID: WP_050872449.1
Location: 4811329..4813065 (1737 bp)
Type: Others
Protein ID: WP_098905182.1
Location: 4813150..4813986 (837 bp)
Type: Others
Protein ID: WP_098905321.1
Location: 4815817..4816299 (483 bp)
Type: Others
Protein ID: WP_098905183.1
Location: 4816540..4816830 (291 bp)
Type: Others
Protein ID: WP_019211216.1
Location: 4816851..4817726 (876 bp)
Type: Others
Protein ID: WP_019211215.1
Location: 4817782..4818801 (1020 bp)
Type: Others
Protein ID: WP_019211214.1
Location: 4818882..4819883 (1002 bp)
Type: Others
Protein ID: WP_019211213.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CRN74_RS223604809508..4810104+597WP_050080822.1response regulator transcription factor-
CRN74_RS223654810303..4810908-606WP_050872449.1response regulator transcription factor-
CRN74_RS223754811329..4813065-1737WP_098905182.1SulP family inorganic anion transporter-
CRN74_RS223804813150..4813986-837WP_098905321.13'-kinase-
CRN74_RS223854814103..4814354+252WP_050080817.1helix-turn-helix domain-containing proteinAntitoxin
CRN74_RS223904814358..4815653+1296WP_050080816.1type II toxin-antitoxin system HipA family toxinToxin
CRN74_RS223954815817..4816299-483WP_098905183.1DUF2501 domain-containing protein-
CRN74_RS224004816540..4816830-291WP_019211216.1(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase-
CRN74_RS224054816851..4817726-876WP_019211215.13-hydroxy-5-phosphonooxypentane-2,4-dione thiolase-
CRN74_RS224104817782..4818801-1020WP_019211214.1autoinducer 2 ABC transporter substrate-binding protein LsrB-
CRN74_RS224154818882..4819883-1002WP_019211213.1autoinducer 2 ABC transporter permease LsrD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 48487.86 Da        Isoelectric Point: 6.5940

>T86507 WP_050080816.1 NZ_CP023962:4814358-4815653 [Yersinia frederiksenii]
MEKLTLALNGIVVGTLEKAAGGEISFFYHDSWLERSGARAISLSLPLQTVKFRGEVVYNFFDNLLPDSESIRSRIQARFQ
TPTKQPFDLLSQIGSDCVGAIQLYPEGRQINSVTEIHATPLNDNEIEKLLLGYKEAPLGMEADIDDFRISLAGAQEKTAL
LWYQNQWHRPEGSTPTSHILKLPIGYIAANGIDLSESVENEWLCLKIAEEFGLPVAYSEIKYFGKQKALVVERFDRRWSP
NNSWLMRLPQEDFCQVLGVAPALKYESDGGPGIADAMKLLLGSQQAIQDRDIFFKSQILFWMLAAIDGHAKNFSVFIELD
SAFRMTPIYDVMSAFPLMHPRGIPAKKAKMAMALLGRNRHFHWSTILPRHFISTAKQVNYPEDNVVQLMAEMKEKTEQVI
AAVKAVLPQGFPEKISEPIFSGLRRQSAKLP

Download         Length: 1296 bp

>T86507 NZ_CP023962:4814358-4815653 [Yersinia frederiksenii]
ATGGAAAAGTTAACCCTTGCATTAAACGGCATCGTAGTTGGTACCTTGGAGAAGGCTGCCGGTGGTGAAATCTCTTTTTT
CTATCATGATAGCTGGCTTGAACGCAGTGGAGCACGTGCGATTTCTCTGTCGTTACCCCTACAAACGGTGAAATTCCGTG
GGGAGGTTGTTTATAATTTTTTTGATAACCTTCTGCCTGACAGTGAATCTATTCGCAGCCGTATTCAAGCGCGTTTTCAA
ACACCAACAAAGCAACCTTTTGATTTACTCTCCCAAATAGGGAGTGATTGCGTAGGGGCAATTCAATTATACCCAGAAGG
CCGGCAAATAAATTCTGTCACCGAGATCCATGCAACGCCTTTAAATGACAATGAGATAGAAAAATTACTCTTAGGGTATA
AGGAGGCGCCTTTGGGCATGGAGGCCGATATTGATGATTTCCGTATTTCTTTGGCTGGGGCACAAGAGAAAACAGCCTTA
CTGTGGTATCAGAATCAATGGCATCGGCCAGAAGGGAGTACACCAACGAGTCATATTCTTAAATTGCCTATAGGCTATAT
AGCCGCTAATGGTATTGATTTAAGTGAAAGTGTCGAGAATGAATGGTTGTGCTTAAAGATTGCTGAAGAATTTGGTCTAC
CTGTCGCGTATTCAGAAATAAAATATTTTGGTAAGCAAAAGGCATTAGTTGTTGAGCGGTTCGATCGCCGCTGGAGCCCT
AATAATAGTTGGTTGATGCGTTTACCGCAGGAGGATTTTTGTCAGGTCTTAGGTGTAGCACCTGCACTCAAATATGAATC
TGATGGTGGTCCTGGGATTGCAGATGCGATGAAACTATTACTCGGTTCTCAGCAAGCGATTCAGGATCGGGATATTTTTT
TTAAAAGTCAGATACTTTTCTGGATGTTAGCCGCGATTGACGGGCACGCGAAGAATTTTAGTGTGTTTATTGAATTGGAT
AGCGCATTTCGTATGACACCCATTTACGATGTGATGTCTGCATTTCCACTCATGCACCCACGAGGAATACCGGCTAAAAA
AGCAAAAATGGCCATGGCATTACTTGGACGTAATCGGCATTTTCACTGGAGTACTATTTTACCTCGGCACTTCATTTCAA
CCGCGAAACAGGTGAATTATCCCGAAGATAATGTTGTGCAATTAATGGCTGAAATGAAAGAAAAAACCGAACAAGTGATA
GCTGCGGTGAAGGCGGTTCTACCACAGGGCTTTCCCGAAAAAATCAGTGAGCCTATTTTCTCTGGTTTAAGGCGGCAGTC
GGCGAAACTGCCCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9584.94 Da        Isoelectric Point: 10.4866

>AT86507 WP_050080817.1 NZ_CP023962:4814103-4814354 [Yersinia frederiksenii]
MKITSAAMLANTLRNERKKSKLTQRKTAETVGLKQSTVSEFENHPDGTKLDTLFKLLAALDLELQVRPRNRNIKDNTTWD
QEW

Download         Length: 252 bp

>AT86507 NZ_CP023962:4814103-4814354 [Yersinia frederiksenii]
ATGAAAATTACCTCTGCTGCAATGTTGGCAAATACACTACGGAATGAACGCAAAAAAAGTAAGCTGACTCAGCGAAAAAC
AGCCGAGACAGTCGGTTTGAAGCAATCAACAGTATCAGAGTTTGAAAACCATCCTGATGGTACCAAATTAGACACGCTGT
TTAAGTTATTGGCAGCACTGGATTTAGAGCTACAGGTTAGGCCAAGGAACCGCAATATTAAGGATAATACAACCTGGGAT
CAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0T9TNV2

Antitoxin

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Source
ID
Structure
No matching records found

References