Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3979897..3980507 Replicon chromosome
Accession NZ_CP023962
Organism Yersinia frederiksenii strain FDAARGOS_417

Toxin (Protein)


Gene name doc Uniprot ID A0A0T9UYD5
Locus tag CRN74_RS18630 Protein ID WP_050083383.1
Coordinates 3980115..3980507 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0T9UY83
Locus tag CRN74_RS18625 Protein ID WP_049610050.1
Coordinates 3979897..3980118 (+) Length 74 a.a.

Genomic Context

CRN74_RS18620CRN74_RS18625CRN74_RS18630CRN74_RS18635CRN74_RS18640CRN74_RS18645CRN74_RS18605CRN74_RS18610CRN74_RS18615CRN74_RS18650CRN74_RS18655
Location: 3978784..3979647 (864 bp)
Type: Others
Protein ID: WP_019212725.1
Location: 3979897..3980118 (222 bp)
Type: Antitoxin
Protein ID: WP_049610050.1
Location: 3980115..3980507 (393 bp)
Type: Toxin
Protein ID: WP_050083383.1
Location: 3980669..3981205 (537 bp)
Type: Others
Protein ID: WP_098905050.1
Location: 3981847..3983457 (1611 bp)
Type: Others
Protein ID: WP_098905051.1
Location: 3983488..3983667 (180 bp)
Type: Others
Protein ID: Protein_3582
Location: 3975434..3976729 (1296 bp)
Type: Others
Protein ID: WP_050083382.1
Location: 3977179..3977826 (648 bp)
Type: Others
Protein ID: WP_049610089.1
Location: 3977938..3978654 (717 bp)
Type: Others
Protein ID: WP_098905049.1
Location: 3983746..3984894 (1149 bp)
Type: Others
Protein ID: WP_050083387.1
Location: 3985100..3985285 (186 bp)
Type: Others
Protein ID: WP_049610039.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CRN74_RS186053975434..3976729-1296WP_050083382.1dicarboxylate/amino acid:cation symporter-
CRN74_RS186103977179..3977826-648WP_049610089.1orotate phosphoribosyltransferase-
CRN74_RS186153977938..3978654-717WP_098905049.1ribonuclease PH-
CRN74_RS186203978784..3979647+864WP_019212725.1YicC family protein-
CRN74_RS186253979897..3980118+222WP_049610050.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
CRN74_RS186303980115..3980507+393WP_050083383.1type II toxin-antitoxin system death-on-curing family toxinToxin
CRN74_RS186353980669..3981205+537WP_098905050.1cysteine hydrolase-
CRN74_RS186403981847..3983457+1611WP_098905051.1FAD-NAD(P)-binding protein-
CRN74_RS186453983488..3983667+180Protein_3582FKBP-type peptidyl-prolyl cis-trans isomerase-
CRN74_RS186503983746..3984894-1149WP_050083387.1pectate lyase-
CRN74_RS186553985100..3985285-186WP_049610039.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(4-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14813.78 Da        Isoelectric Point: 6.9895

>T86505 WP_050083383.1 NZ_CP023962:3980115-3980507 [Yersinia frederiksenii]
MMWISAQEVIAFHDRILQRLPGVTGIPDPGRAEALIYRVQNRTHYEGVTDVFELGATYWVAIARGHIFNDGNKRTAFFVT
MAFLYRNGIRIRDTDNSLENLTVAAATGEKTVDQLSQHLRDLVEHTNQIR

Download         Length: 393 bp

>T86505 NZ_CP023962:3980115-3980507 [Yersinia frederiksenii]
ATGATGTGGATCAGCGCTCAGGAGGTTATCGCTTTTCATGACCGCATATTGCAACGGCTACCCGGCGTTACTGGTATACC
CGATCCCGGCAGGGCCGAAGCACTCATTTATCGGGTGCAAAACCGAACACATTATGAAGGCGTGACAGATGTTTTTGAAC
TCGGCGCCACCTACTGGGTCGCTATCGCTCGTGGACACATTTTTAACGATGGTAATAAACGTACTGCGTTTTTCGTTACC
ATGGCTTTCCTCTATCGCAATGGCATCAGGATCCGTGATACCGATAATTCGCTGGAAAATTTAACGGTAGCGGCAGCGAC
AGGTGAGAAAACCGTTGACCAGTTATCGCAACATCTACGAGATTTGGTGGAACATACTAACCAAATTCGTTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8135.99 Da        Isoelectric Point: 5.5675

>AT86505 WP_049610050.1 NZ_CP023962:3979897-3980118 [Yersinia frederiksenii]
MRTYTSTQARANISEVLDAATHGEPVEITRRDGSSAVVISKAEFETYQNAKLDAEFDVIMQRHGHTVEALTNR

Download         Length: 222 bp

>AT86505 NZ_CP023962:3979897-3980118 [Yersinia frederiksenii]
ATGCGTACTTACACTTCAACCCAAGCTCGAGCAAATATTTCAGAAGTATTGGATGCGGCCACTCATGGCGAACCTGTTGA
AATCACCCGCCGAGACGGTAGCTCGGCAGTGGTTATCAGTAAGGCTGAATTTGAGACATACCAAAACGCTAAGCTTGATG
CAGAGTTCGATGTCATTATGCAACGTCATGGTCATACTGTAGAGGCGCTGACAAACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0T9UYD5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0T9UY83

References