Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3979897..3980507 Replicon chromosome
Accession NZ_CP023962
Organism Yersinia frederiksenii strain FDAARGOS_417

Toxin (Protein)


Gene name doc Uniprot ID A0A0T9UYD5
Locus tag CRN74_RS18630 Protein ID WP_050083383.1
Coordinates 3980115..3980507 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0T9UY83
Locus tag CRN74_RS18625 Protein ID WP_049610050.1
Coordinates 3979897..3980118 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN74_RS18605 3975434..3976729 - 1296 WP_050083382.1 dicarboxylate/amino acid:cation symporter -
CRN74_RS18610 3977179..3977826 - 648 WP_049610089.1 orotate phosphoribosyltransferase -
CRN74_RS18615 3977938..3978654 - 717 WP_098905049.1 ribonuclease PH -
CRN74_RS18620 3978784..3979647 + 864 WP_019212725.1 YicC family protein -
CRN74_RS18625 3979897..3980118 + 222 WP_049610050.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CRN74_RS18630 3980115..3980507 + 393 WP_050083383.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
CRN74_RS18635 3980669..3981205 + 537 WP_098905050.1 cysteine hydrolase -
CRN74_RS18640 3981847..3983457 + 1611 WP_098905051.1 FAD-NAD(P)-binding protein -
CRN74_RS18645 3983488..3983667 + 180 Protein_3582 FKBP-type peptidyl-prolyl cis-trans isomerase -
CRN74_RS18650 3983746..3984894 - 1149 WP_050083387.1 pectate lyase -
CRN74_RS18655 3985100..3985285 - 186 WP_049610039.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(4-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14813.78 Da        Isoelectric Point: 6.9895

>T86505 WP_050083383.1 NZ_CP023962:3980115-3980507 [Yersinia frederiksenii]
MMWISAQEVIAFHDRILQRLPGVTGIPDPGRAEALIYRVQNRTHYEGVTDVFELGATYWVAIARGHIFNDGNKRTAFFVT
MAFLYRNGIRIRDTDNSLENLTVAAATGEKTVDQLSQHLRDLVEHTNQIR

Download         Length: 393 bp

>T86505 NZ_CP023962:3980115-3980507 [Yersinia frederiksenii]
ATGATGTGGATCAGCGCTCAGGAGGTTATCGCTTTTCATGACCGCATATTGCAACGGCTACCCGGCGTTACTGGTATACC
CGATCCCGGCAGGGCCGAAGCACTCATTTATCGGGTGCAAAACCGAACACATTATGAAGGCGTGACAGATGTTTTTGAAC
TCGGCGCCACCTACTGGGTCGCTATCGCTCGTGGACACATTTTTAACGATGGTAATAAACGTACTGCGTTTTTCGTTACC
ATGGCTTTCCTCTATCGCAATGGCATCAGGATCCGTGATACCGATAATTCGCTGGAAAATTTAACGGTAGCGGCAGCGAC
AGGTGAGAAAACCGTTGACCAGTTATCGCAACATCTACGAGATTTGGTGGAACATACTAACCAAATTCGTTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8135.99 Da        Isoelectric Point: 5.5675

>AT86505 WP_049610050.1 NZ_CP023962:3979897-3980118 [Yersinia frederiksenii]
MRTYTSTQARANISEVLDAATHGEPVEITRRDGSSAVVISKAEFETYQNAKLDAEFDVIMQRHGHTVEALTNR

Download         Length: 222 bp

>AT86505 NZ_CP023962:3979897-3980118 [Yersinia frederiksenii]
ATGCGTACTTACACTTCAACCCAAGCTCGAGCAAATATTTCAGAAGTATTGGATGCGGCCACTCATGGCGAACCTGTTGA
AATCACCCGCCGAGACGGTAGCTCGGCAGTGGTTATCAGTAAGGCTGAATTTGAGACATACCAAAACGCTAAGCTTGATG
CAGAGTTCGATGTCATTATGCAACGTCATGGTCATACTGTAGAGGCGCTGACAAACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9UYD5

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9UY83

References