Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3122535..3123207 Replicon chromosome
Accession NZ_CP023962
Organism Yersinia frederiksenii strain FDAARGOS_417

Toxin (Protein)


Gene name cptA Uniprot ID A0A0T9UGW4
Locus tag CRN74_RS14790 Protein ID WP_050082213.1
Coordinates 3122535..3122960 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0T9UGT3
Locus tag CRN74_RS14795 Protein ID WP_019211617.1
Coordinates 3122941..3123207 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN74_RS14770 3118246..3118764 + 519 WP_050082217.1 flavodoxin FldB -
CRN74_RS14775 3118855..3120279 - 1425 WP_098904925.1 cell envelope integrity protein CreD -
CRN74_RS14780 3120371..3121798 - 1428 WP_098904926.1 two-component system sensor histidine kinase CreC -
CRN74_RS14785 3121837..3122535 - 699 WP_049606188.1 two-component system response regulator CreB -
CRN74_RS14790 3122535..3122960 - 426 WP_050082213.1 protein YgfX Toxin
CRN74_RS14795 3122941..3123207 - 267 WP_019211617.1 FAD assembly factor SdhE Antitoxin
CRN74_RS14800 3123459..3124448 + 990 WP_050286434.1 tRNA-modifying protein YgfZ -
CRN74_RS14805 3124533..3125225 - 693 WP_050082335.1 hemolysin III family protein -
CRN74_RS14810 3125470..3126219 - 750 WP_050873675.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16527.43 Da        Isoelectric Point: 9.4189

>T86504 WP_050082213.1 NZ_CP023962:c3122960-3122535 [Yersinia frederiksenii]
VAQWRCDLRISWHTQLFSLLTHGVLVILTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNVVLWKRL
EWIVVKQPWMTRYGVLLRLRQANSRSTCKRLWLAADSMSEDEWRQLCLLLRHSFDADEGHT

Download         Length: 426 bp

>T86504 NZ_CP023962:c3122960-3122535 [Yersinia frederiksenii]
GTGGCCCAGTGGCGATGTGACCTACGTATATCCTGGCACACTCAACTTTTCTCTTTATTGACACATGGTGTCTTGGTCAT
ACTCACGCTGGTCGCACCCTGGCCTCAGGGTTATACCGCGCTGTGGTTAGTATTACTGACGCTGGTAGTCTTTGAGTGTA
TCCGCAGCCAGAAGAATATTACCTCCTGCCAAGGGGAGATCAGGCTGAAACCCGGCAATGTGGTGCTATGGAAACGGCTT
GAATGGATTGTCGTTAAGCAGCCATGGATGACCCGATATGGCGTGTTATTGCGCTTACGGCAGGCAAACAGTCGATCAAC
CTGTAAGCGCCTATGGCTGGCGGCTGATAGCATGTCAGAAGATGAGTGGCGGCAACTTTGTTTGCTATTGCGTCACTCTT
TTGATGCGGATGAAGGGCATACTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10532.06 Da        Isoelectric Point: 4.6786

>AT86504 WP_019211617.1 NZ_CP023962:c3123207-3122941 [Yersinia frederiksenii]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDGLSDSEKQIFIRLLECDDPDLFNWLMNHGEPQDDELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp

>AT86504 NZ_CP023962:c3123207-3122941 [Yersinia frederiksenii]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTGGATATCTCCATCATGCCATT
TTTTGAATACGAATATGATGGCTTGAGTGATAGCGAGAAGCAGATTTTTATTCGGCTACTGGAATGTGATGACCCAGACC
TTTTCAATTGGCTGATGAATCATGGGGAGCCGCAGGATGACGAACTGCGTCAGATGGTGAAATTGATTCAAACGCGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9UGW4

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9UGT3

References