Detailed information of TA system TA086492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 1470625..1471594
• Replicon: chromosome
• Accession: NZ_CP023962
• Organism: Yersinia frederiksenii strain FDAARGOS_417

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0T9TXD8
• Locus tag: CRN74_RS06780
• Protein ID: WP_050081128.1
• Coordinates: 1470625..1471083 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0T9TWM5
• Locus tag: CRN74_RS06785
• Protein ID: WP_050081127.1
• Coordinates: 1471148..1471594 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRN74_RS06750	1466515..1467180	+	666	WP_050285587.1	phage shock protein PspA	-
CRN74_RS06755	1467264..1467491	+	228	WP_019209928.1	envelope stress response membrane protein PspB	-
CRN74_RS06760	1467491..1467865	+	375	WP_050081131.1	envelope stress response membrane protein PspC	-
CRN74_RS06765	1467923..1468162	+	240	WP_098904503.1	phage shock protein PspD	-
CRN74_RS06770	1468143..1469540	+	1398	WP_098904504.1	YcjX family protein	-
CRN74_RS06775	1469537..1470598	+	1062	WP_050081129.1	YcjF family protein	-
CRN74_RS06780	1470625..1471083	-	459	WP_050081128.1	RES family NAD+ phosphorylase	Toxin
CRN74_RS06785	1471148..1471594	-	447	WP_050081127.1	DUF2384 domain-containing protein	Antitoxin
CRN74_RS06790	1471913..1473490	+	1578	WP_057649459.1	transcriptional regulator TyrR	-
CRN74_RS06795	1473632..1474135	-	504	WP_019209936.1	thiol peroxidase	-
CRN74_RS06800	1474290..1475261	+	972	WP_098904505.1	L-Ala-D/L-Glu epimerase	-
CRN74_RS06805	1475266..1475982	-	717	WP_098904506.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (36-90)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17297.66 Da
• Isoelectric Point: 5.1578

>T86492 WP_050081128.1 NZ_CP023962:c1471083-1470625 [Yersinia frederiksenii]
MKLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHSAIYLASSVSLAMLETLAHIQDSSTLSEFELFQIEIDDNNIMLLHPT
DWPIDWRNDPAPATTMDVGTEWLESESSVGLLVPSTLVPSENNMLVNPRHKDFQAYLNSVKPLPFSFDPRLK

Nucleotide

• Length: 459 bp

>T86492 NZ_CP023962:c1471083-1470625 [Yersinia frederiksenii]
ATGAAGCTTTACCGTATTGTGATGCGCCGTTATTTGGCCTCAGCATGGACGGGTTATGGCGCTGAAATCTATGGTGGCCG
CTGGAACCATAAGGGCCACTCCGCGATTTATTTAGCCAGCAGCGTATCGTTAGCGATGTTAGAAACGTTGGCGCATATTC
AAGACAGTTCAACCCTCAGTGAGTTTGAGCTATTTCAAATTGAAATTGATGACAACAATATTATGCTGTTGCATCCAACC
GATTGGCCCATCGACTGGCGCAACGATCCAGCTCCCGCCACGACAATGGATGTTGGCACCGAGTGGTTAGAATCAGAATC
CTCCGTTGGATTACTGGTGCCCTCCACTCTGGTGCCTTCAGAAAATAATATGTTGGTCAATCCACGCCACAAAGACTTTC
AGGCTTACTTGAACAGTGTCAAACCGCTTCCGTTCTCTTTTGATCCGCGGCTGAAATAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16233.65 Da
• Isoelectric Point: 9.1260

>AT86492 WP_050081127.1 NZ_CP023962:c1471594-1471148 [Yersinia frederiksenii]
MRAYHPTPTAKTGALWREIGLPASRGTILVDSIKLGFSVDVIDSIHLWAAIPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT86492 NZ_CP023962:c1471594-1471148 [Yersinia frederiksenii]
ATGAGAGCATATCACCCCACCCCAACCGCCAAAACAGGCGCGCTCTGGCGTGAAATAGGCCTACCCGCCAGCCGCGGCAC
CATCTTGGTCGACAGCATAAAGTTAGGGTTTTCGGTTGACGTTATCGATAGCATTCACCTTTGGGCTGCGATACCTAAAT
CTGAGATTCTACGCGCAACAGGGATCCCCAGCCGTAGCCTGACCCGTCGGCGCACTCATGATGGCCGTTTCACGCCGGAA
GAGAGTGAGCGAATTGCGCGTTTTGTACGCGTCATGGATGCTGCCGTTGATCTTTTTGGTGGCGATAAAGGCAAGGCTAT
CACTTGGATGTCAACACCGATTAAAGGTTTGGGCCACCGCAGTCCTGATTCATTATTAGAGACAGAAACCGGCGCCTTAG
AAGTCTGTGACTTAATTGGGCGGCTGGAGCACGGCGTATTCTCTTAA

Structures

Toxin

• AlphaFold DB: A0A0T9TXD8

Antitoxin

• AlphaFold DB: A0A0T9TWM5