Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 1470625..1471594 Replicon chromosome
Accession NZ_CP023962
Organism Yersinia frederiksenii strain FDAARGOS_417

Toxin (Protein)


Gene name - Uniprot ID A0A0T9TXD8
Locus tag CRN74_RS06780 Protein ID WP_050081128.1
Coordinates 1470625..1471083 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0T9TWM5
Locus tag CRN74_RS06785 Protein ID WP_050081127.1
Coordinates 1471148..1471594 (-) Length 149 a.a.

Genomic Context

CRN74_RS06750CRN74_RS06755CRN74_RS06760CRN74_RS06765CRN74_RS06770CRN74_RS06775CRN74_RS06790CRN74_RS06800CRN74_RS06780CRN74_RS06785CRN74_RS06795CRN74_RS06805
Location: 1466515..1467180 (666 bp)
Type: Others
Protein ID: WP_050285587.1
Location: 1467264..1467491 (228 bp)
Type: Others
Protein ID: WP_019209928.1
Location: 1467491..1467865 (375 bp)
Type: Others
Protein ID: WP_050081131.1
Location: 1467923..1468162 (240 bp)
Type: Others
Protein ID: WP_098904503.1
Location: 1468143..1469540 (1398 bp)
Type: Others
Protein ID: WP_098904504.1
Location: 1469537..1470598 (1062 bp)
Type: Others
Protein ID: WP_050081129.1
Location: 1471913..1473490 (1578 bp)
Type: Others
Protein ID: WP_057649459.1
Location: 1474290..1475261 (972 bp)
Type: Others
Protein ID: WP_098904505.1
Location: 1470625..1471083 (459 bp)
Type: Toxin
Protein ID: WP_050081128.1
Location: 1471148..1471594 (447 bp)
Type: Antitoxin
Protein ID: WP_050081127.1
Location: 1473632..1474135 (504 bp)
Type: Others
Protein ID: WP_019209936.1
Location: 1475266..1475982 (717 bp)
Type: Others
Protein ID: WP_098904506.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CRN74_RS067501466515..1467180+666WP_050285587.1phage shock protein PspA-
CRN74_RS067551467264..1467491+228WP_019209928.1envelope stress response membrane protein PspB-
CRN74_RS067601467491..1467865+375WP_050081131.1envelope stress response membrane protein PspC-
CRN74_RS067651467923..1468162+240WP_098904503.1phage shock protein PspD-
CRN74_RS067701468143..1469540+1398WP_098904504.1YcjX family protein-
CRN74_RS067751469537..1470598+1062WP_050081129.1YcjF family protein-
CRN74_RS067801470625..1471083-459WP_050081128.1RES family NAD+ phosphorylaseToxin
CRN74_RS067851471148..1471594-447WP_050081127.1DUF2384 domain-containing proteinAntitoxin
CRN74_RS067901471913..1473490+1578WP_057649459.1transcriptional regulator TyrR-
CRN74_RS067951473632..1474135-504WP_019209936.1thiol peroxidase-
CRN74_RS068001474290..1475261+972WP_098904505.1L-Ala-D/L-Glu epimerase-
CRN74_RS068051475266..1475982-717WP_098904506.1murein tripeptide amidase MpaA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(36-90)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17297.66 Da        Isoelectric Point: 5.1578

>T86492 WP_050081128.1 NZ_CP023962:c1471083-1470625 [Yersinia frederiksenii]
MKLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHSAIYLASSVSLAMLETLAHIQDSSTLSEFELFQIEIDDNNIMLLHPT
DWPIDWRNDPAPATTMDVGTEWLESESSVGLLVPSTLVPSENNMLVNPRHKDFQAYLNSVKPLPFSFDPRLK

Download         Length: 459 bp

>T86492 NZ_CP023962:c1471083-1470625 [Yersinia frederiksenii]
ATGAAGCTTTACCGTATTGTGATGCGCCGTTATTTGGCCTCAGCATGGACGGGTTATGGCGCTGAAATCTATGGTGGCCG
CTGGAACCATAAGGGCCACTCCGCGATTTATTTAGCCAGCAGCGTATCGTTAGCGATGTTAGAAACGTTGGCGCATATTC
AAGACAGTTCAACCCTCAGTGAGTTTGAGCTATTTCAAATTGAAATTGATGACAACAATATTATGCTGTTGCATCCAACC
GATTGGCCCATCGACTGGCGCAACGATCCAGCTCCCGCCACGACAATGGATGTTGGCACCGAGTGGTTAGAATCAGAATC
CTCCGTTGGATTACTGGTGCCCTCCACTCTGGTGCCTTCAGAAAATAATATGTTGGTCAATCCACGCCACAAAGACTTTC
AGGCTTACTTGAACAGTGTCAAACCGCTTCCGTTCTCTTTTGATCCGCGGCTGAAATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16233.65 Da        Isoelectric Point: 9.1260

>AT86492 WP_050081127.1 NZ_CP023962:c1471594-1471148 [Yersinia frederiksenii]
MRAYHPTPTAKTGALWREIGLPASRGTILVDSIKLGFSVDVIDSIHLWAAIPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLIGRLEHGVFS

Download         Length: 447 bp

>AT86492 NZ_CP023962:c1471594-1471148 [Yersinia frederiksenii]
ATGAGAGCATATCACCCCACCCCAACCGCCAAAACAGGCGCGCTCTGGCGTGAAATAGGCCTACCCGCCAGCCGCGGCAC
CATCTTGGTCGACAGCATAAAGTTAGGGTTTTCGGTTGACGTTATCGATAGCATTCACCTTTGGGCTGCGATACCTAAAT
CTGAGATTCTACGCGCAACAGGGATCCCCAGCCGTAGCCTGACCCGTCGGCGCACTCATGATGGCCGTTTCACGCCGGAA
GAGAGTGAGCGAATTGCGCGTTTTGTACGCGTCATGGATGCTGCCGTTGATCTTTTTGGTGGCGATAAAGGCAAGGCTAT
CACTTGGATGTCAACACCGATTAAAGGTTTGGGCCACCGCAGTCCTGATTCATTATTAGAGACAGAAACCGGCGCCTTAG
AAGTCTGTGACTTAATTGGGCGGCTGGAGCACGGCGTATTCTCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0T9TXD8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0T9TWM5

References