Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4382763..4383597 Replicon chromosome
Accession NZ_CP023960
Organism Escherichia coli strain FDAARGOS_448

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E0IX31
Locus tag CRN68_RS23890 Protein ID WP_000854689.1
Coordinates 4382763..4383140 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0IVP8
Locus tag CRN68_RS23895 Protein ID WP_001285599.1
Coordinates 4383217..4383597 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN68_RS29320 4379157..4379312 - 156 WP_000729638.1 hypothetical protein -
CRN68_RS23865 4379744..4380677 - 934 Protein_4091 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
CRN68_RS23870 4380670..4381065 - 396 WP_000208382.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
CRN68_RS23875 4381134..4381979 - 846 WP_001446750.1 DUF4942 domain-containing protein -
CRN68_RS23880 4382064..4382261 - 198 WP_000839250.1 DUF957 domain-containing protein -
CRN68_RS23885 4382278..4382766 - 489 WP_000761698.1 hypothetical protein -
CRN68_RS23890 4382763..4383140 - 378 WP_000854689.1 TA system toxin CbtA family protein Toxin
CRN68_RS23895 4383217..4383597 - 381 WP_001285599.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CRN68_RS23900 4383647..4384291 - 645 WP_000086757.1 hypothetical protein -
CRN68_RS23905 4384310..4384531 - 222 WP_000692315.1 DUF987 domain-containing protein -
CRN68_RS23910 4384594..4385070 - 477 WP_001186761.1 RadC family protein -
CRN68_RS23915 4385086..4385559 - 474 WP_023351915.1 antirestriction protein -
CRN68_RS23920 4385823..4386644 - 822 WP_099004483.1 DUF945 domain-containing protein -
CRN68_RS29325 4386745..4386954 - 210 Protein_4103 DUF905 domain-containing protein -
CRN68_RS23935 4387055..4387510 - 456 WP_001309747.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4379157..4379312 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14042.07 Da        Isoelectric Point: 9.1510

>T86486 WP_000854689.1 NZ_CP023960:c4383140-4382763 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T86486 NZ_CP023960:c4383140-4382763 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13984.78 Da        Isoelectric Point: 5.0823

>AT86486 WP_001285599.1 NZ_CP023960:c4383597-4383217 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT86486 NZ_CP023960:c4383597-4383217 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGTTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References